- Postdoctoral training - Reproductive Cancer Biology - Columbia University
- Ph.D - Biochemistry, Cellular & Molecular Biology - Syracuse University
- M.Sc - Biotechnology - Indian Institute of Technology Bombay
- B.Sc - Biochemistry (honors) - University of Delhi
- ANFS345 - Animal Physiology
- ANFS475 - Veterinary Biochemistry
- ANFS865 - Graduate Seminar
Research in the Dutta laboratory is focused on understanding the mechanistic basis of cellular response to oxidative stress in both normal and diseased states, and the role of the microbiome in this process. In particular, the laboratory studies mitochondria-mediated mechanisms involved in the development and maintenance of reproductive organ systems. The laboratory utilizes state-of-the-art transcriptomic, proteomic, and metabolomic approaches to interrogate chicken models, mouse models, and human samples. The work aims to improve reproductive efficiency in chickens to enhance farm productivity; and identify and define drivers of prostate and ovarian cancer in the human context.
Le Magnen C, Virk RK, Dutta A, Kim JY, Panja S, Lopez-Bujanda ZA, Califano A, Drake CG, Mitrofanova A, Abate-Shen C. Cooperation of loss of NKX3.1 and inflammation in prostate cancer initiation. Disease Models & Mechanisms. 2018 dmm.035139 doi: 10.1242/dmm.035139.
Dutta A, Panja S, Virk RK, Kim JY, Zott R, Cremers S, Golombos, DM, Liu D, Mosquera JM, Mostaghel EA, Barbieri CE, Mitrofanova A, Abate-Shen C. Co-clinical analysis of a genetically engineered mouse model and human prostate cancer reveals significance of NKX3.1 expression for response to 5α-reductase inhibition. European Urology. 2017 Oct; 72(4): 499-506
Dutta A#, Choudhary P#, Caruana J, Raina R. JMJ27, an Arabidopsis H3K9 histone demethylase, modulates defense against Pseudomonas syringae and flowering time. Plant Journal. 2017 Sep;91(6):1015-1028 (#Equal contribution)
Dutta A#, Le Magnen C#, Mitrofanova A, Ouyang X, Califano A, and Abate-Shen C. Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science. 2016 Jun 24;352(6293):1576-80. (# Equal contribution)
Le Magnen C#, Dutta A#, and Abate-Shen C. Optimizing mouse models for precision cancer prevention. Nature Reviews Cancer. 2016 Mar;16(3):187-96. (# Equal contribution)
Dutta A, Chan S, Pauli NT, and Raina R. Hypersensitive Response-Like Lesions 1 codes for Atppt1 and regulates accumulation of ROS and defense against bacterial pathogen Pseudomonas syringae in Arabidopsis thaliana. Antioxidants & Redox Signaling. 2015 Mar