Chemistry 652 - - - ORGANOMETALLIC CHEMISTRY - - - Spring 2007

Instructor:

Prof. Klaus H. Theopold, 214 Lammot du Pont Lab phone: 1546

e-mail: theopold@udel.edu

Class Schedule:

Tuesdays & Thursdays 2:00 - 3:15 PM in ALS 322

Required text: R. H. Crabtree, The Organometallic Chemistry of the Transition Metals, 4^rd edition.

The following books provide more information and/or different viewpoints and may be found in the Library.

1. Collman, Hegedus, Norton, Finke; Principles and Applications of Organotransition

Metal Chemistry, 2^nd edition.

2. Elschenbroich; Salzer; Organometallics, 2^nd edition.

3. Kochi; Organometallic Mechanisms and Catalysis.

4. Parshall, Ittel; Homogeneous Catalysis, 2^nd edition.

5. Atwood; Inorganic and Organometallic Reaction Mechanisms, 2^nd edition.

6. Huheey; Keiter, and Keiter; Inorganic Chemistry, 4^th edition

7. Cotton, Wilkinson; Advanced Inorganic Chemistry, 6^th edition.

Examinations/Homework:

Midterm (in class, on April 5).

A paper - in the form of a review - see below for details (due on May 8).

Comprehensive final (during finals week, date and time to be announced).

Grading:

Midterm 30 %

Paper 30 %

Final 40 %

Total: 100 %

Pick your favorite organometallic chemist — i.e. somebody who has been contributing a substantial body of work to the field - (let me know who - first come, first serve!) Identify the 5 (+/-1) most significant papers (pertaining to organometallic chemistry) that person has published during his/her career; a citation analysis may be a good way to start on this!

Write a summary of your chemist’s contribution (5 - 10 pages, including figures), based on your close reading/analysis of these five most significant papers. This should include a description of the topic and the main results of the papers, as well as putting them into a larger context (i.e. other contributors in the area, current thinking) and any critical thoughts of yours.

Approximate Syllabus:

1 - Introduction: History, 18-electron rule, ligands

2 - Ligands cont’d, characterization & fluxionality

3 - Reductive Elimination/Oxidative Addition

4 - Migratory Insertion/Elimination

5 - Nucleophilic/Electrophilic attack on coordinated ligands

6 - Metal-carbon Multiple Bonds, Olefin Metathesis, ROMP

7 - CO-chemistry, hydroformylation, Fischer-Tropsch process, etc.

8 - Olefin-chemistry, isomerization, hydrogenation, polymerization

9 - oxidation, high-oxidation state organometallics, O₂-activation.

10 - C-H activation

11 - Main group organometallics.

12 - Applications in organic synthesis