CHEM-642 Biochemistry
Tentative Schedule  -  Spring 2001

Meeting Time and Place: Section 10 meets 9:30 to 10:45 AM Tuesdays and Thursdays in 203 Brown Laboratory. Section 11 meets 7 to 8:15 PM Tuesdays and Thursdays in 203 Brown Laboratory. Because morning and evening lectures will be presented by the same professor and because there will be common hourly and final examinations for both sections, students may attend either or both lectures providing seats are available in the small lecture room. The first half of the course will be taught by Prof. Hal White and the second half by Prof. Junghuei Chen. Text chapters and sections in parentheses refer to Garrett and Grisham's, Biochemistry.  Copies of the overheads used by Dr. Chen will be on reserve in the Chemistry Library in Brown Laboratory after Spring Break.
 

Tuesdays 9:30-10:45 AM & 7:00-8:15 PM Thursdays 9:30-10:45 AM & 7:00-8:15 PM
February 6
Introduction and Review of Metabolic Principles 
       (Chapter 18.1-18.3)		 February 8

Glycogen Synthesis and Degradation 
       (Chapter 23.3 - 23.5) Pentose Phosphate Pathway  (Chapter 23.6) 
 
February 13
Oxidation of Odd-Chain Length and 
       Unsaturated Fatty Acids, Lipid Structure 
       (Chapter 8) 
Biosynthesis of Lipids (Chapter 25) 
Problem Set 1 due		 February 15
Ketone Body Formation (Chapter 24.3-24.6) 
Biosynthesis of Lipids cont. (Chapter 25) 
Membranes & Selected Topics 
       (Chapters 9 & 10)
February 20
Lipid Metabolism and Membranes cont. 
        (Chapters 9, 10, and 25) 
Problem Set 2 due		 February 22
Lipid Metabolism and Membranes cont. 
       (Chapters 9, 10, & 25)
February 27
Nitrogen Acquisition and Excretion 
        (Chapter 26) 
Problem Set 3 due		 March 1 
Amino Acid Metabolism  (Chapter 26)
March 6
Amino Acid Metabolism cont. (Chapter 26) 
Problem Set 4 due		 March 8
Amino Acid Metabolism cont. (Chapter 26)
March 13
Integration of Metabolism and Review for 
        Midterm Examination		 March 15
Overview of Nucleotide Metabolism 
         (Chapters 11 & 27) 
(First Hour Exam Saturday March 18, 
10 AM - noon in 101 Brown Laboratory.)
March 20
Introduction to Molecular Biology 		 March 22
No class in lieu of the out-of-class midterm 
        examination on March 18
March 27    SPRING BREAK March 29    SPRING BREAK
April 3
Structure and Function of DNA, History of the experiments showing DNA is the Genetic material.		 April 5
Properties of DNA, Secondary structure, Supercoiling and linking numbers
April 10
Topoisomerases, DNA packing, Chromosome structure.		 April 12
DNA replication in prokaryotes and eukaryotes, Central Dogma
April 17
Primosomes and Replisomes, DNA polymersaes, Mechanism of replication		 April 19
Eukaryotic replication, "Reverse transcriptase," Mutation and DNA repair
April 24
DNA epair continued, Recombination and its enzymology.		 April 26
Recombination continued, Immunoglobulin somatic recombination,  Lambda phage, Transposons.
May 1
Transcription, RNA Polymerase, Transcription Regulation in prokaryotes, Lac operon.		 May 3
Transcription factors and termination in eukaryotes, RNA Processing, Catabolite activation
May 8
Translation		 May 10
Translation continued 
Second Hour Exam based on Dr. Chen's lectures on Saturday, May 12 from 10 - noon in 101 Brown Laboratory 
May 15
Recombinant DNA methodology		 Final Comprehensive Examination
7 to 10 PM Monday, May 21 in 101 Brown Lab 


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Last updated 24 April 2001 by Hal White.
Copyright 2001, Harold B. White, Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716