Molecular Genetic Blood Analysis

 

Introduction -- By Jason R Remy

 With the advent of modern genetics, it has become possible to look at the very essence of what makes us unique, our DNA. From highly publicized criminal cases we have seen how genetics can be used to determine guilt or innocence. We have gain ed a new understanding of disease, both in diagnosing and treatment. It is now possible to diagnose the fetus, with great accuracy, while it is still in the womb. All of these new tools, however, are not without their societal impact. While it is the posi tion of those working on the articles you find here that the advancement of human knowledge should never be discouraged, it is still important to recognize that with this new knowledge must come new responsibility.

 Article 1: Forensics -- By Jaimie Smith

A brief overview of modern genetic tools utilized in the forensic laboratory.

 Article 2: Disease Part I: Sickle Cell Anemia-- By Piyush Shukla

 An illustrated look at the genetic disease Sickle Cell Anemia.

 Article 3: Disease Part II: Huntington's Disease -- By Brian McCormick

 A brief overview of the symptoms and diagnosis of the neurological disorder known as Huntington's Disease.

 Article 4: Modern Prenatal Diagnosis: Chorionic Villus Sampling -- By Jason R Remy

 A look at CVS, a common modern method for diagnosis prenatal disease very early in pregnancy.

Conclusions -- By Brian McCormick and Jason R Remy

While these new genetic technologies will increase our knowledge of genetics, and its application to such diverse areas as forensics, disease, and prenatal care, there are some social and ethical aspects which must be evaluated before abuses of these n ew technologies are used in irresponsible ways. It has been estimated that there is a single gene defect in one out of every hundred live births. Imagine being asked to submit a blood sample for genetic evaluation on a job interview, applying for medical insurance, or applying for a mortgage. Should we be able to pick and choose the kind of genetic traits we'd like to see in our offspring? If we know about the potential diseases that our offspring will have long before they are born, how will we handle th at information? Although a person may be in good health and show no symptoms of any disease, they may be refused employment or insurance based on their genetic make-up. Should people who fail a genetic screening be denied a mortgage or the right to have c hildren? These are all questions that we as a society need to answer fairly soon.

It is our position that the advancement of knowledge is never a bad thing. Scientists need to continue to study genetics, and its potential applications. The benefits of these new discoveries far outweigh the potential problems. Imagine never having a false conviction in court, as suspects can be declared guilty or innocent based on DNA testing. Once the cause for a disease is found, it can be corrected. Scientists are currently working on ways to treat and hopefully cure such genetic diseases as Sickl e Cell Anemia and Huntington's Disease. And prenatal testing will help parents to better prepare for potential problems, as genetic disorders can now be treated from birth, or even earlier, instead of waiting for the onset of symptoms. The problems outlin ed above are societal ones, and not related to the science being studied. A society that discriminates unfairly on the basis of inborn traits is wrong, regardless of the level of technology present in that society.

 Furthur Readings --

A sampling of books and web sites you may find informative.

This page was written by Piyush Shukla, Jaimie Smith, Jason R Remy, and Brian McCormick, and edited by Jason R Remy. It is located at http://www.udel.edu/chem/C465/senior/fall97/blood_II/intro.html . Last updated 11/24/97.