diane chugani

Diane Chugani Headshot

Diane Chugani

Professor
 302-831-3301

Office Location:
523 Tower at STAR

Education

  • Post-doctoral Fellow, Biological Chemistry, University of California, 1988
  • Ph.D., Pharmacology, University of California, 1986
  • B.A., Psychology, University of Maryland, 1979

Research Interests

  • Neurodevelopment Disorders
  • Autism Spectrum Disorder
  • Neuroimaging
  • Molecular Imaging
  • Clinical Trials

Honors, Awards, Major Professional Office Held

  • NIH (NICHD) Mental Retardation Center Trainee Fellowship, UCLA (1986-1988)
  • Milestone Award from the Mental Illness Research Association (1997)
  • Ring of Hope Award from the Pheasant Ring Foundation (2001)
  • Executive Committee, International Society for Autism Research (2001, 2002)
  • Appointed to Autism Research Program Integration Panel for the US Army Medical Research and Material Command (2009-present)
  • Invited panelist, The White House, April 27, 2011
  • Member, Dana Alliance for Brain Initiative, 2011 to present
  1. TLR7 activation in epilepsy of tuberous sclerosis complex. Dombkowski AA, Cukovic D, Bagla S, Jones M, Caruso JA, Chugani HT, Chugani DC. Inflamm Res. 2019 Sep 11. doi: 10.1007/s00011-019-01283-3. [Epub ahead of print] PMID: 31511910.
  2. Automated production of a N-methyl-D-aspartate receptor radioligand [18F]GE179 for clinical use. Yue X, Xin Y, Chugani HT, Chugani DC, Zhang S. Appl Radiat Isot. 2019 Jun;148:246-252. doi: 10.1016/j.apradiso.2019.03.035. Epub 2019 Mar 27. PMID: 310.
  3. Linking spherical mean diffusion weighted signal with intra-axonal volume fraction. Li H, Chow HM, Chugani DC, Chugani HT.Magn Reson Imaging. 2019 Apr;57:75-82. doi: 10.1016/j.mri.2018.11.006. Epub 2018 Nov 12. PMID: 30439515.
  4. Minimal number of gradient directions for robust measurement of spherical mean diffusion weighted signal. Li H, Chow HM, Chugani DC, Chugani HT. Magn Reson Imaging. 2018 Dec;54:148-152. doi: 10.1016/j.mri.2018.08.020. Epub 2018 Aug 30. PMID: 30171997.
  5. Trajectory of inflammatory and microglial activation markers in the postnatal rabbit brain following intrauterine endotoxin exposure. Zhang Z, Jyoti A, Balakrishnan B, Williams M, Singh S, Chugani DC, Kannan S. Neurobiol Dis. 2018 Mar;111:153-162. doi: 10.1016/j.nbd.2017.12.013. Epub 2017 Dec 21. PMID: 29274431 Free PMC Article
  6. A distinct microRNA expression profile is associated with α[11C]-methyl-L-tryptophan (AMT) PET uptake in epileptogenic cortical tubers resected from patients with tuberous sclerosis complex. Bagla S, Cukovic D, Asano E, Sood S, Luat A, Chugani HT, Chugani DC, Dombkowski AA. Neurobiol Dis. 2018 Jan;109(Pt A):76-87. doi: 10.1016/j.nbd.2017.10.004. Epub 2017 Oct 7. PMID: 28993242 Free PMC Article.
  7. Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain. Williams M, Zhang Z, Nance E, Drewes JL, Lesniak WG, Singh S, Chugani DC, Rangaramanujam K, Graham DR, Kannan S. Dev Neurosci. 2017;39(5):399-412. doi: 10.1159/000471509. Epub 2017 May 11. PMID: 28490020 Free PMC Article.
  8. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Sahin M, Henske EP, Manning BD, Ess KC, Bissler JJ, Klann E, Kwiatkowski DJ, Roberds SL, Silva AJ, Hillaire-Clarke CS, Young LR, Zervas M, Mamounas LA; Tuberous Sclerosis Complex Working Group to Update the Research Plan. Pediatr Neurol. 2016 Jul;60:1-12. doi: 10.1016/j.pediatrneurol.2016.03.015. Epub 2016 Apr 2. PMID: 27267556 Free PMC Article.
  9. Autism Spectrum Disorders in Africa: Current Challenges in Identification, Assessment, and Treatment: A Report on the International Child Neurology Association Meeting on ASD in Africa, Ghana, April 3-5, 2014. Ruparelia K, Abubakar A, Badoe E, Bakare M, Visser K, Chugani DC, Chugani HT, Donald KA, Wilmshurst JM, Shih A, Skuse D, Newton CR. J Child Neurol. 2016 Jul;31(8):1018-26. doi: 10.1177/0883073816635748. Epub 2016 Mar 15. Review. PMID: 26979098
  10. Efficacy of Low-Dose Buspirone for Restricted and Repetitive Behavior in Young Children with Autism Spectrum Disorder: A Randomized Trial.
    Chugani DC, Chugani HT, Wiznitzer M, Parikh S, Evans PA, Hansen RL, Nass R, Janisse JJ, Dixon-Thomas P, Behen M, Rothermel R, Parker JS, Kumar A, Muzik O, Edwards DJ, Hirtz D; Autism Center of Excellence Network.
    J Pediatr. 2016 Mar;170:45-53.e1-4. doi: 10.1016/j.jpeds.2015.11.033. Epub 2015 Dec 30.
    PMID: 26746121 Free Article
  11. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference.
    Sahin M, Henske EP, Manning BD, Ess KC, Bissler JJ, Klann E, Kwiatkowski DJ, Roberds SL, Silva AJ, Hillaire-Clarke CS, Young LR, Zervas M, Mamounas LA; Tuberous Sclerosis Complex Working Group to Update the Research Plan. Pediatr Neurol. 2016 Jul;60:1-12. doi: 10.1016/j.pediatrneurol.2016.03.015. Epub 2016 Apr 2. Review.
    PMID: 27267556
  12. Autism Spectrum Disorders in Africa: Current Challenges in Identification, Assessment, and Treatment: A Report on the International Child Neurology Association Meeting on ASD in Africa, Ghana, April 3-5, 2014.
    Ruparelia K, Abubakar A, Badoe E, Bakare M, Visser K, Chugani DC, Chugani HT, Donald KA, Wilmshurst JM, Shih A, Skuse D, Newton CR. J Child Neurol. 2016 Jul;31(8):1018-26. doi: 10.1177/0883073816635748. Epub 2016 Mar 15.
    PMID: 26979098
  13. Multi-modal imaging of tumor cellularity and Tryptophan metabolism in human Gliomas.
    Jeong JW, Juhász C, Mittal S, Bosnyák E, Kamson DO, Barger GR, Robinette NL, Kupsky WJ, Chugani DC.
    Cancer Imaging. 2015 Aug 6;15:10. doi: 10.1186/s40644-015-0045-1.
    PMID: 26245742 Free PMC Article
  14. Cortical Tubers: Windows into Dysregulation of Epilepsy Risk and Synaptic Signaling Genes by MicroRNAs.
    Dombkowski AA, Batista CE, Cukovic D, Carruthers NJ, Ranganathan R, Shukla U, Stemmer PM, Chugani HT, Chugani DC.
    Cereb Cortex. 2016 Mar;26(3):1059-71. doi: 10.1093/cercor/bhu276. Epub 2014 Dec 1.