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Jae Kyeom Kim

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Publications

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Jae Kyeom Kim

Assistant Professor
jkkim@udel.edu
 302-831-7536

Office Location:
204D Delaware Technology Park

Jae Kyeom Kim, MS, PhD is an Assistant Professor in the Department of Behavioral Health and Nutrition and a Principal Investigator of the Nutrigenomics Lab at the University of Delaware. Dr. Kim received his PhD from University of Minnesota in 2013 and started his first professorship at the University of Arkansas before joining the UD. Dr. Kim’s research focuses on molecular mechanisms by which environmental factors can influence the etiology of preventable chronic diseases (e.g., non-alcoholic/alcohol related liver diseases and colon cancer). Specifically, Dr. Kim aims to elucidate the implications of dietary constituents (e.g., alcohol, added sugar, and specific vegetable families) in hepatic metabolism of xenobiotics such as a dietary carcinogen, PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine). Dr. Kim also has put effort into establishing a research program with specific emphasis in the establishment/utilization of genetically engineered mouse models of diseases [e.g., isocitrate dehydrogenase 2 knockout mice for gastrointestinal cancers/liver diseases, cytochrome P450 1A1 and 1A2 humanized mice for colon cancer, and apolipoprotein E-deficient mice for atherosclerosis]. Last, in conjunction with bioinformatics analyses (e.g., Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, or Ingenuity Pathway Analysis tools), Dr. Kim adopts multi-omics approaches to capture global impacts of dietary interventions and to characterize experimental models. The unbiased approaches we utilize include transcriptomics, proteomics, targeted/untargeted metabolomics (in both serum and urine), and microRNomics.

 

Education

  • PhD, Nutritional Biochemistry, 2013
  • MS, Food Science and Biotechnology, 2009
  • BS, Food Science and Biotechnology, 2007

Courses

NTDT867: Nutritional Genomics

NTDT631: Advanced Micronutrient Metabolism

NTDT467: Genetics in Health and Nutrition

Selected Publications

  • Pan JH, Cha HB, Tang J, Lee S, Lee SK, Le B, Redding MC, Kim SY, Batish M, Kong B*, Lee JH*, and Kim JK*. The role of microRNA-33 as a key regulator in hepatic lipogenesis signaling and a potential serological biomarker for NAFLD with excessive dietary fructose consumption in C57BL/6N mice. 2021; Food Func. (DOI: 10.1039/D0FO02286A)
  • Pan JH, Kim HJ, Tang J, Beane K, Kong S, Kong B, Kim YJ, Shin EC, Kim JH, Lee JH, and Kim JK*. Acute alcohol consumption-induced let-7a inhibition exacerbates hepatic apoptosis by regulating Rb1 in mice. 2020; Alcohol. 85 (4): 13-20
  • Pan JH, Tang J, Beane K, Redding MC, Cho YJ, Kim YJ, Zhao J, Shin EC, Lee JH, Kong B, and Kim JK*. Hepatic transcriptomics reveals that fructose exposure downregulated xenobiotics metabolizing enzymes through aryl hydrocarbon receptor signaling suppression in C57BL/6N mice. Br. J. Nutr. 2019; 122 (7): 769-779
  • Kim JK, Park JH, Lim YJ, Kim YJ, Park JW, and Lee JH. Naringin protects acrolein-induced pulmonary toxicity through modulation apoptotic signaling and inflammation signaling pathways in mice. J. Nutr. Biochem. 2018; 59 (9): 10-16 
  • Kim JK, Gallaher DD, and Trudo SP. Apiaceous vegetable intake modulates expression of DNA damage repair signaling pathway genes and microRNAs in Wistar rat colon. 2018; J. Func. Food. 45 (6): 138-145
  • Kim JK, Strapazzon N, Gallaher CM, Stoll DR, Thomas W, Gallaher DD, and Trudo SP. Comparison of short- and long-term exposure effects of cruciferous and apiaceous vegetables on carcinogen metabolizing enzymes in Wistar rats. 2017; Food Chem. Tox. 108 (Part A): 194-202 
  • Pan JH, Abernathy B, Kim YJ, Lee JH, Kim JH, Shin EC, and Kim JK*. Cruciferous vegetables and colorectal cancer prevention through microRNA regulation: a review. 2017; Crit. Rev. Food Sci. Nutr. 58 (12): 2026-2038 
  • Kim JK, Gallaher DD, Chi Chen, Gallaher CM, Dan Yao, and Trudo SP. PEITC and I3C from cruciferous vegetables but not furanocoumarins in apiaceous vegetables reduced PhIP-induced DNA adducts in Wistar rats. 2016; Mol. Nutr. Food Res. 60 (9): 1956-1966 
  • Kim JK, Gallaher DD, Chi Chen, Dan Yao, and Trudo SP. Intake of apiaceous vegetables decreases PhIP-induced genotoxicity and increases methylated PhIP metabolites in the urine metabolome in rats. J. Nutr. 2015; 145 (3): 442-451

Research Interests

  • Nutrigenomics

  College of Health Sciences

Academic Departments

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