Dr. Hajime Sakai

 

 

RESEARCH INTERESTS:

My group is interested in several aspects of flower and seed development. Our goal is to discover genetic pathways that could lead to improvement of crop traits. One of our focuses is the development of seed at very early stages. Currently, we are investigating the interaction between endosperm and embryo, which marks one of the most conspicuous reproduction processes of flowering plants. We are also interested in molecular mechanisms specifying cell fate and controlling cell proliferation in plants. Our studies employ reverse as well as forward genetic approaches in two model systems, Arabidopsis and rice. To understand global cross talks between genes, we also utilize various genomic methodologies in our studies.

EDUCATION AND TRAINING:

 Postdoctoral Fellow in the lab of Dr. Elliot Meyerowitz
 California Institute of Technology
 Pasadena, California, USA
 http://www.caltech.edu/~meyerowitz/
 
 Postdoctoral Fellow in the lab of Dr. Wolfhard Bandlow
 Institute for Genetics and Microbiology
 University of Munich, Munich, Germany
 
 Ph.D. Genetics
 University of Munich, Munich, Germany
 
 Diplom Biology
 University of Munich, Munich, Germany
 
 Hokkaido University, Sapporo, Japan
 

CURRENT POSITION:
 
 Senior Research Scientist, Principal Investigator
 DuPont, Agriculture and Nutrition, Molecular Genetics
 Newark, DE
 

PUBLICATIONS (SELECTED):
 
Sakai, H., Taramino, G., Nagasawa, N., Miao, G.-H., Vogel, J., Tingey, S.V. Development of genomics approaches for crop trait improvement. In Rice Genetics IV, International Rice Research Institute (in press).
 
Sakai H., Krizek B.A., Jacobsen S.E., and Meyerowitz E.M. 2000. Regulation of SUP expression identifies multiple regulators involved in Arabidopsis floral meristem development. Plant Cell, 12: 1607-18.
 
Jacobsen, S.E., Sakai, H., Finnegan, E.J., Cao, X., and Meyerowitz, E.M. 2000. Ectopic hypermethylation of flower-specific genes in Arabidopsis. Curr Biol. 10: 179-86.
 
Hua, J., Sakai, H., Nourizadeh, S., Chen, Q.G., Bleecker, A.B., Ecker, J.R., and E.M. Meyerowitz. 1998. EIN4 and ERS2 are members of the putative ethylene receptor gene family in Arabidopsis. Plant Cell, 10: 1321-1332.
 
Sakai, H., Hua, J., Chen, Q.G., Chang, C., Bleecker, A.B., Medrano, L.J., and E.M. Meyerowitz. 1998. ETR2 is an ETR1-like gene involved in ethylene signaling in Arabidopsis. Proc. Natl. Acad. Sci. USA, 95: 5812-5817.
 
Meyerowitz, E.M., Running, M.P., Sakai, H., and R.W. Williams. 1997. Multiple modes of cell division control in Arabidopsis flower development. In Symposia of the society for experimental Biology: Control of plant Development; genes and signals. The Company of Biologists Limited. Cambridge, UK.
 
Hua, J., Sakai, H., and E.M. Meyerowitz. 1997. The ethylene receptor gene family in Arabidopsis. In Biology and Biotechnology of the Plant Hormone Ethylene. (ed. A.K. Kanellis), pp 71-76 Kluwer Academic Publishers, Netherlands.
 
Sakai, H., Medrano, L.J., and E.M. Meyerowitz. 1995. Role of SUPERMAN in maintaining Arabidopsis floral whorl boundaries. Nature 378:199-203.
 
Clark, S.E., Sakai, H., and E.M. Meyerowitz. 1994. Inflorescence development in clavata mutants. In Arabidopsis: An Atlas of Morphology and Development (ed. J. L. Bowman), pp. 214-215. Springer-Verlag, New York.
 
Bowman, J.L., Sakai, H., Jack, T., Weigel, D., Mayer, U., and E.M. Meyerowitz. 1992. SUPERMAN, a regulator of floral homeotic genes in Arabidopsis. Development 114:599- 615.
 

CONTACT INFORMATION:

 Address:
 DuPont, Agricultural Biotechnology
 Delaware Technology Park 200, 1 Innovation Way
 Newark, DE 19714-6104
 
 Phone:
 (302) 631-2651
 
 Fax:
 (302) 631-2607
 
 E-Mail:
 Hajime.Sakai@usa.dupont.com

 



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Created July 1998
Last updated December 13, 2000

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