Dr. S. Carl Falco
 
 
Date and Place of Birth:

June 24, 1949; Elizabeth, New Jersey

Education:

1971, A.B. (Physics), Rutgers College, New Brunswick, New Jersey.

1977, Ph.D., Department of Biophysics and Theoretical Biology, University of Chicago, Illinois.  Thesis Advisor, Dr. L. B. Rothman-Denes.

Training and Fellowships:

1976-1977:  Teaching Assistant, University of Chicago.

1978:   Instructor, Massachusetts Institute of Technology.

1979:   Teaching Associate, Massachusetts Institute of Technology.

1978-1981:  Postdoctoral Fellow, Laboratory of Dr. D. Botstein, Massachusetts Institute of Technology.

Professional Experience:

1981-1986:  Research Scientist, Central Research & Development Department, E. I. du Pont de Nemours & Co., Inc.

1983-1986:  Adjunct Professor, Department of Life and Health Sciences, University of Delaware.
 
1987-present:  Research Fellow, Agricultural Products Department, E. I. du Pont de Nemours & Co., Inc.

Honors, Awards, Professional Recognition:

1967-1969:  American Chemical Society Scholarship
1971:   Phi Beta Kappa
1971:   Bachelor of Arts awarded with High Honors and Distinction in Physics
1977:   Marc Perry Galler Award for doctoral dissertation
1977-1981: National Institutes of Health Postdoctoral Fellowship
1990:   Dupont Agricultural Products Scientific Leadership Award

PUBLICATIONS:

Research papers:

Falco, S. C., Vander Laan, K., and Rothman-Denes, L. B.  (1977)  "Viron-associated RNA polymerase required for bacteriophage N4 development"  Proc. Nat. Acad. Sci. USA 74, 520-523.

Vander Laan, K., Falco, S. C., and Rothman-Denes, L. B.  (1977)  "The program of RNA synthesis in N4-infected Escherichia coli"  Virology 76, 596-601.

Falco, S. C., Zivin, R., and Rotham-Denes, L. B.  (1978)  "Novel template requirements of N4 virion RNA polymerase."  Proc. Nat. Acad. Sci. USA 75, 3220-3224.

Falco, S. C. and Rotham-Denes, L. B.  (1979)  "Bacteriophage N4-induced transcribing activities in Escherichia coli.  I. Detection and characterization in cell extracts"  Virology 95, 454-465.

Falco, S. C. and Rotham-Denes, L. B.  (1979)  "Bacteriophage N4-induced transcribing activities in Escherichia coli.  II. Association of the N4 transcriptional apparatus with the cytoplasmic membrane"  Virology 95, 466-475.

Botstein, D., Falco, S. C., Stewart, S. E., Brennan, M., Scherer, S., Stinchcomb, D. T., Struhl, K., and Davis, R. W.  (1979)  "Sterile Host Yeasts (SHY):  A eukaryotic system of biological containment for recombinant DNA experiments" Gene. 8, 17-24.

Falco, S. C., Zehring, W., and Rothman-Denes,  L. B.  (1980) "DNA dependent RNA polymerase from bacteriophage N4 virions:  Purification and characterization."  J. Biol. Chem. 255, 4339-4347.

Falco, S. C., Li, Y., Broach, J. R., and Botstein, D.  (1982)  "Genetic properties of chromosomally integrated 2 micron plasmid DNA in yeast"  Cell 29, 573-584.

Zehring, W. A., Falco, S. C., Malone, C., and Rothman-Denes, L. B.  (1983)  "Bacteriophage  N4-induced transcribing activities in E. coli.  III.  A third cistron required for N4 RNA polymerase II activity"  Virology 126, 678-687.

Falco, S. C., Rose, M., and Botstein, D.  (1983)  "Homologous recombination between episomal plasmids and chromosomes in yeast"  Genetics 105, 843-856.

Falco, S. C. and Botstein, D.  (1983)  "Rapid chromosomal mapping of cloned segments of yeast DNA"  Genetics 105, 857-872.

Falco, S. C. and Dumas, K. S.  (1985)  "Genetic analysis of mutants of Saccharomyces cerevisiae resistant to the herbicide sulfometuron methyl"  Genetics 109, 21-35.

Falco, S. C., Dumas, K. S., and Livak, K. J.  (1985)  "Nucleotide sequence of the yeast ILV2 gene which encodes acetolactate synthase"  Nucleic Acids Res. 13, 4011-4027.

Golin, J. E., Falco, S. C., and Margolskee, J. P.  (1986)  "Coincident gene conversion in yeast that involve a large insertion"  Genetics 114, 1081-1094.

Van Dyk, T. K., Falco, S. C., and LaRossa, R. A.  (1986)  "Rapid physical mapping by transposon Tn5 mutagenesis to localize the cloned yeast ILV2 gene"  Appl. & Env. Micro. 51, 206-208.

Yadav, N. S., McDevitt, R. E., Benard, S., and Falco, S. C.  (1986)  "Single amino acid substitutions in the enzyme acetolactate synthase confer resistance to the herbicide sulfometuron methyl"  Proc. Natl. Acad. Sci. USA.  83, 4418-4422.

Guinta, D., Stambouly, J., Falco, S. C., Rist, J. K., and Rothman-Denes, L. B.  (1986)
"Host and phage-coded functions required for coliphage N4 DNA replication"  Virology 150, 33-44.

Rafalski, J. A., and Falco, S. C. (1988)  "Structure of the yeast HOM3 gene which encodes aspartokinase"  J. Biol. Chem. 263, 2146-2151.

Golin, J. E., and Falco, S. C. (1988) "The behavior of insertions near a site of mitotic gene conversion in yeast"  Genetics 119, 535-540.

Leppert, G., McDevitt, R., Falco, S. C., Van Dyk, T. K., Ficke, M.B., and Golin, J. (1990) "Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces"  Genetics 125,13-20.

Chui, C-F., and Falco, S. C., (1995) "A  new methionine-rich seed storage protein from maize"  Plant Physiol. 107, 291.

Falco, S. C., Guida, T., Locke, M., Mauvais, J., Sanders, C., Ward, R. T., and Webber, P. (1995) "Transgenic canola and soybean seeds with increased lysine"  Biotechnology 13, 577-582.

Keeler, S. J., Maloney, C. L., Webber, P. Y., Patterson, C., Hirata, L. T., Falco, S. C., and Rice, J. A. (1997) “Express of de novo high-lysine a-helical coiled-coil proteins may significantly increase the accumulated levels of lysine in mature seeds of transgenic tobacco plants”, Plant Mol. Biol. 34, 15-29.

Epelbaum, S., McDevitt, R. and Falco, S. C., (1997) “Lysine-ketoglutarate reductase and saccharopine dehydrogenase from Arabidopsis thaliana: nucleotide sequence and characterization”, Plant Mol. Biol. 35, 735-748.

Book Chapters and Reviews:

Rist, J. K., Guinta, D. R., Sugino, A., Stambouly, J., Falco, S. C., and Rotham-Denes, L. B.  (1983)  "Bacteriophage N4 DNA replication."  In:  UCLA Symposia on Molecular and Cellular Biology, Alan R. Liss, Inc., NY.

LaRossa, R. A. and Falco, S. C.  (1984)  "Amino acid biosynthetic enzymes as targets of herbicide action"  Trends in Biotech. 2, 158-161.

Falco, S. C., Dumas, K. S., and McDevitt, R. E.  (1985)  "Molecular genetic analysis of  sulfonylurea herbicide action and resistance in yeast"  In:  Molecular Form and Function of the Plant Genome, Plenum, NY.

Falco, S. C., Chaleff, R. S., Dumas, K. S., LaRossa, R. A., Leto K. J., Mauvais, C. J.,
Mazur, B. J., Ray, T. B., Schloss, J. V., and Yadav, N. S.  (1985)  "Molecular biology of  sulfonylurea herbicide activity"  In:  Biotechnology in Plant Science:  Relevance to Agriculture in the Eighties, Academic Press, Inc., l

Mazur, B. J., Chui, C.-F., Falco, S. C., Chaleff, R. S., and Mauvais, C. J.  (1985)  "Cloning herbicide resistance genes into and out of plants"  In:  The World Biotech Report 1985, Online International, NY.

LaRossa, R. A., Falco, S. C., Mazur, B. J., Livak, K. J., Schloss, J. V., Smulski, D. R.,
Van Dyk, T. K., and Yadav, N. S.  (1987)  "Microbiological identification and characterization of an amino acid biosynthetic enzyme as the site of sulfonylurea herbicide action"  In:  Biotechnology in Agricultural Chemistry.  American Chemical Society, Washington, D.C.

Falco, S. C., Dumas, K. S., McDevitt, R. E., and Golin, J. E.  (1987)  "Molecular biology of sulfonylurea herbicide action on Saccharomyces cerevisiae"  In:  Biological Research on Industrial Yeasts.  CRC Press, Inc., Boca Raton, FL.

Chaleff, R. S., Sebastian, S. A., Creason, G. L., Mazur, B. J., Falco, S. C., Ray, T. B., Mauvais, C. J., and Yadav, N. S.  (1987)  "Developing plant varieties resistant to sulfonylurea herbicides"  In:  Molecular Strategies for Crop Protection.  Alan R. Liss, Inc.

Falco, S. C., Knowlton, S., LaRossa, R. A., Smith, J. K., and Mazur, B. J.  (1987) "Herbicides that inhibit amino acid biosynthesis:  the sulfonylureas - a case study"  In:  Proceedings of the British Crop Protection Conference - Weeds"  BCPC Publications, Surrey, UK.

Mazur, B. J., Falco, S. C., Knowlton, S., and Smith, J. K. (1987) "Acetolactate synthase, the target enzyme of the sulfonylurea herbicides"  In: Proceedings of the NATO Advanced Study Institute "Plant Molecular Biology", Plenum Press.

Falco, S. C., McDevitt, R. E., Chui, C.-F., Hartnett, M. E., Knowlton, S., Mauvais, C. J.,  Smith, J. K., and Mazur, B. J. (1989) "Engineering herbicide resistant acetolactate synthase", Devel. Industrial Microbiol. 30, 187-194.

Mazur, B. J. and Falco, S. C. (1989) "The development of herbicide resistant crops", Ann. Rev. Plant Physiol. Plant. Mol. Biol. 40, 441-470, Annual Reviews Inc.

Hartnett, M. E.,  Chui, C.-F., Mauvais, C. J., McDevitt, R. E., Knowlton, S., Smith, J. K.,  Falco, S. C., and Mazur, B. J. (1990) "Herbicide resistant plants carrying mutated acetolactate  synthase genes"  In Managing Resistance to Agrochemicals: From Fundamental Research to Practical Strategies, Green, M. B., Moberg, W. K. and LeBaron, H., eds., American Chemical Society.

Falco, S. C., Guida, T., Locke, M., Sanders, C., and Ward, R. T. (1997) “Using bacterial genes to engineer plants with increased seed lysine”, SIM News 47, 53-57.

U. S. patents:

U. S. Patent 4,626,505 (1986)
Falco, S. C., "Selectable markers for yeast transformation".

U. S. Patent 5,013,659 (1991),
U. S. Patent 5,141,870 (1992),
U. S. Patent 5,378,824 (1995),
U. S. Patent 5,605,011 (1997)
Bedbrook, J. R., Chaleff, R. S., Falco, S. C., Mazur, B. J., Somerville, C. R., Yadav, N. S., "Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase".

U. S. Patent 5, 559, 223 (1996)
Falco, S. C., Keeler, S. J., Rice, J. A., "Synthetic storage proteins with defined structure containing programmable levels of essential amino acids for improvement of the nutritional quality of plants".

Patents Pending:

WO 9214822 (1992) Chui, C-F., Falco, S. C., Knowlton, S., Rice, J. A., "A high sulfur seed protein gene and method for increasing the sulfur amino acid content of plants".

PCT/US93/06412 (1993) Falco, S. C., "Chimeric genes and methods for increasing the lysine and threonine content of the seeds of plants".

PCT/US94/13190 (1994) Falco, S. C., "Chimeric genes and methods for increasing the lysine content of the seeds of corn, soybean and rapeseed plants".

PCT/US95/05545 (1995) Falco, S. C., Guida, A. D., Locke, M. E. H., "Nucleic acid fragments, chimeric genes and methods for increasing the methionine content of the seeds of plants".

 



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Last updated July 15,1998

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