Dr. Parent's Research Laboratory
Yersinia pestis, a facultative
gram-negative bacillus, is the causative agent of plague.
Recent vaccine trials, using a Y. pestis specific protein-subunit in
the generation high antibody titers however, vaccination failed to
against a lethal pneumonic infection. Given
that the current vaccine generates robust humoral immunity yet does not
against pneumonic infection, we hypothesized that cell-mediated
immunity is required
in addition to humoral immunity for complete protection.
Toward that end, my lab is focusing on identifying
and understanding those aspects of the immune response needed to
lethal pneumonic infection. Using mouse
models, different vaccination regimens and attenuated Y. pestis our
is to understand the underlying mechanisms of a protective immune
against Y. pestis in order to produce a more efficacious
My laboratory currently has openings for a
and Ph.D. student. Also, I am looking for motivated
undergraduate students interested in a research
experience. Please contact Dr. Parent for additional information.