Please try again. A gallbladder disorder is often characterized by jaundice, a yellow discoloration of the skin, sclera, and body fluids. Bile pigments can crystallize as the gallbladder concentrates bile, which can eventually lead to the formation of gallstones. When a gallstone is permanently lodged in the main bile duct, the bile flow is blocked, backs up in the liver, and spills into the blood. The presence of bilirubin, or bile pigment, in the blood leads to jaundice. Excess bilirubin can also be detected in the urine.