Case Study: Dark Urine after Strep Throat


A 3-year-old male was diagnosed with strep throat and prescribed to take penicillin to treat the disease.  His mother is also a believer in curative treatment, so she made sure her son took three vitamins everyday in addition to the penicillin.  However, one week later, his mother noticed that he had dark brown urine which persisted for days and was urinating less frequently than usual.  When she took her son to the physician, a routine urinalysis was performed and the results were as follows:

Color: Amber                                               Protein (mg/dL): Small                          Blood: Small
Appearance: Hazy                                        Glucose: Negative                                 Urobilinogen (mg/dL): 0.2
Specific Gravity: 1.012                                 Ketones: Negative                                 Nitrite: Negative
pH: 5.0                                                        Bilirubin: Negative                                Leukocytes: Moderate

Microscopic
50-100 RBC/hpf
20-50 WBC/hpf
2-5 RBC casts/hpf
10-20 Squamous Epithelial Cells
0-2 Renal Epithelial Cells
Calcium Oxalate crystals


Reference Ranges


1. What is the major discrepancy between the microscopic and chemical results?  What is the cause of the discrepancy?
Answer


2. In general, what other chemical tests can be affected by the cause of the discrepancy in question 1?  HINT: The discrepancy is not present in this case for any chemical tests other than blood.
Answer


3. What type of cell is shown below?  Is it indicative of the disease that is causing the dark urine?
Answer

KMS2-3
x400


4. Does the presence of the crystals shown below correlate with the results of the routine urinalysis?  If so, what conditions are needed for the crystals to form?
Answer

KMS2-4
x400


5. What is the probable diagnosis for this patient?
Answer





Case Study 1

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