Woman with Diabetes

A 20-year-old woman is complaining of frequent urination, dehydration, fatigue, and rapid weight loss. She claims that her urine has a sweet, fruity scent.  After visiting the doctor, she is diagnosed with type 1 diabetes mellitus. Her urinalysis results were:

Color: yellow  (varies) Protein: 3+ (negative) Blood: negative
(negative)
Appearance: hazy  (varies) Glucose: 200 mg/dL
(negative)
Urobilinogen: 0.2 mg/dL
(0.1-1.0 mg/dL)
Specific gravity: 1.025
(random: 1.010- 1.025)
Ketones: small (negative) Nitrite: negative (negative)
pH: 6.0 (5.0-8.0) Bilirubin: negative (negative) Leukocyte: small
(negative)
(**Reference Range**)

Clinitest: negative

Microscopic
Few yeast   (none)
15-20 wbc/hpf   (0-5/hpf)
3-5 squamous epithelial cells/hpf  (0-5/hpf)



1) What is causing the high specific gravity?  ANSWER

2) What is causing the presence of ketones in the urine?  ANSWER

3) Is there a discrepancy between the chemical glucose result and the Clinitest? ANSWER

4) Could ascorbic acid have possibly interfered with this particular Clinitest result?  ANSWER

5) Why is the presence of this formed element (400x) not a concern?  ANSWER

                 Image 1

6) What is this formed element (400x), and why would it be present in this patient's sample?  ANSWER

                    Image 2

7) Based on the chemical results, what other confirmatory tests, besides the Clinitest, need to be run?  ANSWER

***Go to case study #1***
 For more urinalysis case studies, visit: http://www.udel.edu/medtech/mclane/UAcases.html

References


Brunzel, Nancy A. Fundamentals of Urine and Body Fluid Analysis. Philadelphia: Saunders, 2004.

"Type 1 Diabetes." MayoClinic. 24 Oct 2007. 21 Nov 2008 <http://www.mayoclinic.com/health/type-1-diabetes/DS00329>.