PPT Slide

Evolution of Influenza Virus

Changes in Surface Antigens

Neuraminidase

Hemagglutinin

Sialic Acid Residues

Host Cell Surface Glycoproteins

Virus Infection

Virus Release

Mutation

Selection

Genetic Variation

Favorable

Phenotypes

Unfavorable

Phenotypes

Phenotypic

Effect

Genetic Drift

Host

Responses

Fever

Antibodies

SynonymousMutations

Recombination

Segmented RNA

Genome

Co-infected

Host Cell

Pandemics

Antigenic

Shift

1918

Spanish

Flu

1957

Hong Kong

Flu

Replication

5 Other

Proteins

Antigenic Drift

RNA

Polymerase

High Mutation

Rate

Amino Acid

Replacements

CHEM-647 Biochemical Evolution

Concept Map for Case Study 4

University of Delaware

H. B. White 10/24/97

associated

primarily with

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known as

produces sudden

that

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and

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to

such as

of

the

Non-synonymous

Mutations

that operates on

provide

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