Hyaluronic Acid

Hyaluronic Acid

(poly d-glucuronic acid-n-acetyl-d-glucosamine) sodium salt, tetragonal form.

Source: human (homo sapiens) umbilical cord.
Author: S.Arnott

Journal: J.M. Guss, D.W.L. Hukins, P.J.C. Smith, W.T. Winter,S. Arnott, R. Moorhouse, D.A. ReesHyaluronic Acid, Molecular Conformations and Interactions in Two Sodium Salts; J.Mol.Biol. v. 95 359 1975astm jmobak uk issn 0022-2836 070

Reference 1:P.J.C. Smith, S. ArnottA Linked-*Atom Least-*SquaresReciprocal-*Space Refinement System Incorporating Stereochemical Restraints To Supplement Sparse Diffraction Data Acta Crystallogr.,Sect.A V. 34 3 1978Astm Acacbn Dk Issn 0567-7394 108

Reference 2:W.T. Winter, P.J.C. Smith, S. ArnottHyaluronic Acid, Structure Of A Fully Extended3-Fold Helical Sodium Salt And Comparison WithThe Less Extended 4-Fold Helical Forms J.Mol.Biol. V. 99 219 1975Astm Jmobak Uk Issn 0022-2836 070

resolution. 3.0 angstroms.

Refinement. by a linked-atom least-squares model-building procedure. see reference 1 above.

The crystallographic asymmetric unit of this structure comprises one gcu-nag pair of residues. In order to allowfacile generation of the long chain which realistically represents the structure, coordinates for the chain segment limited by the unit-cell repeat distance in the z direction are given here. By repeated translation of 33.94 angstroms in the z direction the full structure of the polymer may be obtained.


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