DRI Patient-Specific Modeling

Researchers at the Delaware Rehabilitation Institute will pursue a multidisciplinary, collaborative approach to address mechanisms of osteoarthritis (OA) along with prevention and treatment. The continuation of this pursuit is afforded by COBRE funding through the National Institutes of Health.


The overall goal of the proposed COBRE is to expand and develop the research capabilities and infrastructure for University of Delaware faculty to enable a multi-scale approach, addressing the problem from a cellular level (Cythomechanics Core) to a larger system’s scale focusing on muscle and joint function (Patient-Specific Modeling Core).

Our core has three aims:

  • Enhance functionality and compatibility of existing and novel tools (motion capture, imaging, modeling) to streamline data collection and processing to extract clinically useful measures.

  • Develop and apply musculoskeletal modeling and simulation tools for COBRE projects that provide insight to muscle coordination, task-specific function and tissue loading.

  • Share modeling approaches to OA and clinical outcomes with the local and global community through workshops and Web-based resources.

Integration of key PSM Core components, below, with clinical research studies will provide insight into mechanisms of disease progression and will shape future intervention approaches:

  • Motion Capture. The PSM Core has facility space and personnel available to assist with the design and execution of research involving motion capture. Aid with data collection and processing agreements, and data quality monitoring can be provided as a part of this component.

  • Imaging. The PSM Core has facility space and personnel available to assist with the design and execution of research involving imaging. Aid with image scanning and processing routines, image digitization and reprocessing, as well as management duties such as equipment maintenance, service contract agreements, and data quality monitoring can be provided as a part of this component.

  • Biomechanical Modeling. The PSM Core has facility space and personnel available to assist with the application and integration of biomechanical modeling. The modeling component of the PSM core can provide expertise in a wide range of modeling applications and techniques including inverse dynamics, musculoskeletal modeling, EMG-driven modeling, forward dynamics simulations, and induced acceleration analysis.

There are multiple ways to take advantage of the array of PSM Core services including specialized workshops and training opportunities, resources and content available on the Web, and a fee-for-service model to provide extended support. Contact Karen Hough, Outreach Coordinator, to find out more.