DRI Patient-Specific Modeling

Researchers at the Delaware Rehabilitation Institute will pursue a multidisciplinary, collaborative approach to address mechanisms of osteoarthritis (OA) along with prevention and treatment. The continuation of this pursuit is afforded by COBRE funding through the National Institutes of Health.


The overall goal of the proposed COBRE is to expand and develop the research capabilities and infrastructure for University of Delaware faculty to enable a multi-scale approach, addressing the problem from a cellular level (Cythomechanics Core) to a larger system’s scale focusing on muscle and joint function (Patient-Specific Modeling Core).

Our core has three aims:

  • Enhance functionality and compatibility of existing and novel tools (motion capture, imaging, modeling) to streamline data collection and processing to extract clinically useful measures.

  • Develop and apply musculoskeletal modeling and simulation tools for COBRE projects that provide insight to muscle coordination, task-specific function and tissue loading.

  • Share modeling approaches to OA and clinical outcomes with the local and global community through workshops and Web-based resources.

Integration of key PSM Core components, below, with clinical research studies will provide insight into mechanisms of disease progression and will shape future intervention approaches:

  • Motion Capture. The PSM Core has facility space and personnel available to assist with the design and execution of research involving motion capture. Aid with data collection and processing agreements, and data quality monitoring can be provided as a part of this component.

  • Imaging. The PSM Core has facility space and personnel available to assist with the design and execution of research involving imaging. Aid with image scanning and processing routines, image digitization and reprocessing, as well as management duties such as equipment maintenance, service contract agreements, and data quality monitoring can be provided as a part of this component.

  • Biomechanical Modeling. The PSM Core has facility space and personnel available to assist with the application and integration of biomechanical modeling. The modeling component of the PSM core can provide expertise in a wide range of modeling applications and techniques including inverse dynamics, musculoskeletal modeling, EMG-driven modeling, forward dynamics simulations, and induced acceleration analysis.

There are multiple ways to take advantage of the array of PSM Core services including specialized workshops and training opportunities, resources and content available on the Web, and a fee-for-service model to provide extended support. Contact Karen Hough, Outreach Coordinator, to find out more.

Resources:

Category
Item Description
Vendor
Specs
Room

Motion Capture

Video-based analysis of human movement

Qualisys

8 high-speed (500 fps), 4 megapixel OQUS 500 cameras, Qualisys Track Manager Software, 64 integrated analog channels. Annual service contract 3.6k

STAR 122

    Motion Analysis Corp. 8 high-speed Raptor-4 cameras, 64 integrated analog channels, Cortex Software, SIMM Real-time plug-in. Annual service contract 9k STAR 116
Split-belt Treadmill Force Measurement Bertec Split-belt, variable speed instrumented treadmill with platforms under each belt and instrumented handrails. STAR 116
Biodex Dynamometer Muscle Strength Testing Biodex Biodex System III isokinetic testing machine; research configured with analog output of torque, velocity& position STAR 122
EMG Neuromuscular Activation Patterns Motion Lab Systems 2 x MA300 16 channels of pre-amplifiedanalog signals with 200 kHz throughput (32 channels of EMG). Additional analog channels are available for foot switches, electrogoniometers and other sensors. Annual service contract 2.5k STAR 122
    Noraxon 16 channels of wired (Telemyo 1400A) & 16 channels of wireless (Telemyo 1200) re-amplified analog signals. Additional analog channels are available for foot switches, electrogoniometers and other sensors. STAR 116/122
Inertial Sensors 3D Motion Analysis Noraxon 5 wireless myoMotion inertial sensors use 3D accelerometer, gyroscope, and magnetometer data to calculate 3D rotation angles of segments STAR 122
Ultrasound Muscle/Tendon Imaging GE Logic e and Logic P6 scanners with cross beam imaging & phase inversion harmonics. Both systems have extended field of view capabilities for imaging large structures. Annual service contract 2.5 k & 7.5k STAR 122/125
    Aloka SSD-5000 variable frequency, 60 mmlinear array transducer for scnning musculoskeletal structures  
Medical Image Processing Digitizing Wacom 3 Wacom interactive pen display systems for the segmentation of MR and CT images. Dedicated computer workstations for image processing, rendering and data analysis  
VO2 Metabolic Testing Cortex MetaMax 3B system can wirelessly measure O2 uptake, CO2 output, ventilation, and heart rate. STAR 116