Patient Specific Modeling
The overall goal of the proposed COBRE is to expand and develop the research capabilities and infrastructure for University of Delaware faculty in order to enable excellent multidisciplinary, collaborative research to address mechanisms of OA as well as its prevention and treatment. This approach is multi-scale in nature addressing the problem from a cellular level (Cythomechanics Core) to a larger system’s scale focusing on muscle & joint function (Patient-Specific Modeling Core). Our core has three aims:
- Enhance functionality and compatibility of existing and novel tools (motion capture, imaging and modeling) to streamline data collection and processing to extract clinically useful measures.
- Develop and apply musculoskeletal modeling and simulation tools for COBRE projects which provide insight to muscle coordination, task specific function and tissue loading.
- Share modeling approaches to OA and clinical outcomes with the local and global community through workshops and web-based resources.
Integration of PSM Core components with clinical research studies will provide insight into mechanisms of disease progression and will shape future intervention approaches. Key components coordinated through the PSM Core include:
The PSM Core has facility space and personnel available to assist with the design and execution of research involving motion capture. Aid with data collection and processing greements, and data quality monitoring can be provided as a part of this component.
The PSM Core has facility space and personnel available to assist with the design and execution of research involving imaging. Aid with image scanning and processing routines, image digitization and reprocessing, as well as management duties such as equipment maintenance, service contract agreements, and data quality monitoring can be provided as a part of this component.
The PSM Core has facility space and personnel available to assist with the application and integration of biomechanical modeling. The modeling component of the PSM core can provide expertise in a wide range of modeling applications and techniques including, inverse dynamics, musculoskeletal modeling, EMG-driven modeling, forward dynamics simulations, and induced acceleration analysis.
There are mutiple ways to take advantage of the array of PSM Core services including specialized workshops and training opportunities, resources and content avaiable on the web, and a fee-for-service model to provide extended support.