William C. Rose

Assistant Professor
Kinesiology & Applied Physiology
148 Human Performance Lab
302-831-1064
rosewc@udel.edu

Research Interests

• Control of blood pressure and flow
• Mathematical modeling of the circulation
• Biomedical signal processing

Introduction to the Computational Physiology Lab

Introduction of the Study

Education

• Ph.D., Biomedical Engineering, Johns Hopkins University, 1989
• A.B., Physics, Harvard University, 1981

Professional Experience

• 2007-present, Assistant Professor, Health, Nutrition, and Exercise Sciences, University of Delaware
• 2005-2007, Instructor, Nursing, University of Delaware
• 1998-2005, Instructor (part time), Biology, Biomechanics and Movement Science, University of Delaware
• 1992-1997, Scientist, Biocomputation Group, DuPont Company
• 1989-1991, Postdoctoral Fellow, Cardiology, Johns Hopkins University

Courses

• BMSC 601/HESC 667, Mathematics and Signal Processing for Biomechanics
• HESC 310, Pre-clinical Anatomy and Physiology
• HESC 667, Survey of Medical Physiology
• NURS 621, Advanced Pathophysiology
• ELEG 672/ELEG 472, Cell and Molecular Biology for Engineers

Selected Publications

• Wenner, M.M., Rose, W.C., Delaney, E.P., Stillabower, M.E., Farquhar, W.B., Influence of plasma osmolality on baroreflex control of sympathetic activity, Am. J. Physiol. 293: H2313-H2319, 2007.
• Manal, K., Rose, W.C., A general solution for the time delay introduced by a low-pass Butterworth digital filter: An application to musculoskeletal modeling, J. Biomech. 40: 678-681, 2007.
• Rogers, R.F., Rose, W.C., Schwaber, J.S., Simultaneous encoding of carotid sinus pressure and dP/dt by NTS target neurons of myelinated baroreceptors, J. Neurophysiol 76: 2644-2660, 1996.
• Rose, W.C., Rybak, I., Schwaber, J.S., Closed loop model of vagally-mediated baroreflex control of heart rate, Proc. 1995 IEEE Eng. Med. Biol. Conf., 1995.
• Braatz, R.D., Ogunnaike, B.A., Schwaber, J.S., Rose, W.C. Autoregulation in Industrial Processes. In Modeling and Control in Biomedical Systems: Proceedings of the 1994 IFAC Symposium, ed. B.W. Patterson, 1994.
• Carden, S.R., Rose, W.C., Schwaber, J.S., Ungar,L.H. The role of baroreceptor resetting in habituating control of blood pressure, Proceedings of the 1994 American Control Conference, 1994.
• Graves, E.B., Rose, W.C., Richter, D.W., Schwaber, J.S., Network Model of the Respiratory Rhythm. In Computation and Neural Systems, eds. F.H. Eeckman, J.M. Bower. Kluwer Academic Publishers: Boston, 1993.
• Rose, W.C., Shoukas, A.A. Two-Port Analysis of Systemic Venous and Arterial Impedances. Am. J. Physiol. 265: H1577-H1587, 1993.
• Rose, W.C., Balke, C.W., Wier, W.G., Marban, E. Macroscopic and unitary properties of physiological ion flux through L-type calcium channels in guinea-pig heart cells. J. Physiol. 456: 267-284, 1992.
• Balke, C.W., Rose, W.C., Marban, E., Wier, W.G. Macroscopic and unitary properties of physiological ion flux through T-type calcium channels in guinea-pig heart cells. J. Physiol. 456: 247-265, 1992.
• Balke, C.W., Rose, W.C., O’Rourke, B., Mejia-Alvarez, R., Backx, P., Marban, E. Biophysics and physiology of cardiac calcium channels. Circulation, 1992.
• Lawrence, J.H., Rose, W.C., Yue, D.T., Marban, E. Sodium channel inactivation from resting states. J. Physiol. 443: 629-650, 1991.
• Kusuoka, H., Rose, W.C., Marban, E. Excitation-contraction coupling in stunned myocardium. In Cardiac Electrophysiology, Circulation, and Transport, eds. S. Sideman, R. Beyar, A.G. Kleber. Kluwer Academic Publishers: Boston, 1991.

Honors, Awards

• Center for Research Development, “Development of a global model of pressure and flow in the human systemic arterial vascular bed”, College of Health Sciences, University of Delaware (2005), Role: Principle Investigator
• Tau Beta Pi (Engineering Honor Society); A.B. cum laude, Harvard University