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Mary Ann McLane

Mary Ann McLane

Professor
Medical Laboratory Sciences
305-G Willard Hall Educ. Bldg.
302-831-8737
mclane@udel.edu

 

 

 


Education

  • BS- Neumann University, Clinical Laboratory Science 1976
  • MS- Temple University, Medical Technology Education 1980
  • PhD- Temple University, Physiology 1993

    Post-Doctoral- Temple University Thrombosis Research Center 1993-96

Research Interests

  • Cancer metastasis
  • Evidence-based medicine
  • Patient safety

Professional Experience

  • 1996 - present Professor, Department of Medical Laboratory Sciences, University of Delaware
  • 1981 - 1990 Assistant Professor, Department of Clinical Laboratory Science, Temple University, Philadelphia PA

Significant Awards

  • Carnegie Foundation US Professor of the Year (Delaware), 2010
  • Lindback Award for Excellence in Teaching, UD, May 2002
  • Robin H. Mendelson Memorial Award, American Society for Clinical Laboratory Science, 2001, 2011
  • ADVANCE Laboratorian of the Year, 1999

Grantsmanship

  • Eastern Pennsylvania-Delaware Geriatric Education Center (7/1/10-6/30/15): Clinical laboratory testing in the elderly population (Co-PI), $41,525
  • NIH-INBRE (5/1/09 – 2/28/12): Direct interaction of eristostatin with melanoma cell surface molecules, $163,060
  • The Milheim Foundation (8/1/07 – 7/31/08) Natural inhibitor of melanoma cell activity, $10,000
    GUR grant, University of Delaware (6/1/07 – 5/30/08): Human immunity, melanoma and the viper venom protein eristostatin, $6000
  • National Institutes of Health (1 R01 CA098056)(4/1/03-3/31/07): Naturally occurring inhibitor of melanoma metastasis, $735,276
  • National Institutes of Health (1 R15 CA90316) (4/1/01 - 3/31/04): Investigation of a naturally occurring inhibitor of melanoma metastasis, $150,000
  • University of Delaware Center for Teaching Effectiveness: Effectiveness of Web-based Coursework in Learning Laboratory Mathematics (1999-2000), $2500
  • UDRF grant (1998-99): Molecular basis for disintegrin selectivity and potency with integrin receptors, $30,000
  • Investigatorship, Amer. Heart Assn (1996-98): Importance of the structure of the RGD loop in disintegrins for integrin recognition, $66,000

Selected Publications

  • Laudicina R, Fenn JA, Freeman V, McCoy C, McLane MA, Mundt L, Polancic J, Randolph T, Shanahan K. Research in Clinical Laboratory Science: Professionals’ Involvement. Clin Lab Sci 24: 235-242, 2011.
  • Kini RM, Clemetson KJ, Markland FS, McLane MA, Morita T (ed). Toxins and Hemostasis: From Bench to Bedside. New York, Springer Science, 2010. ISBN 978-90-481-9294-6
  • McLane MA, Joerger T, Mahmoud A. Disintegrins in health and disease. Frontiers in Bioscience 13: 6617-6637, 2008.
  • Tian J, Paquette-Straub C, Sage EH, Funk S, McLane MA. Inhibition of melanoma cell motility by the snake venom disintegrin eristostatin. Toxicon 49: 899-908, 2007.
  • McLane MA, Paquette-Straub C. Classification and nomenclature of disintegrins isolated from snake venoms. Registry of Exogenous Hemostatic Factors of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis 2007; DOI: 10.1111/j.1538-7836.2007.02671.x
  • McLane MA, Zhang X, Tian J, Zelinskas C, Srivastava A, Hensley B, Paquette-Straub C.Scratching below the surface: Wound healing and alanine mutagenesis provide unique insights into interactions between eristostatin, platelets and melanoma cells. Pathophys Haemost Thromb, 34: 164-168, 2005
  • McLane MA, Kuchar, MA, Brando C, Santoli D, Paquette-Straub CA, Miele ME. New insights on disintegrin-receptor interactions: Eristostatin and melanoma cells, Haemostasis 31: 3-6, 177-182, 2001.
  • Brando C, Marcinkiewicz C, Goldman B, McLane MA, Niewiarowski S. EC3, a heterodimeric disintegrin from Echis carinatus, inhibits human and murine a4 integrin and attenuates lymphocyte infiltration of Langerhans islets and salivary glands in non-obese diabetic mice. Biochem Biophys Res Commun 267: 413-417, 2000.
  • Wierzbicka-Patynowski I, Marcinkiewicz C, Calvete JJ, Marcinkiewicz MM, Niewiarowski S, McLane MA. Structural requirements of echistatin for the recognition of avb3 and a5b1 integrins. J Biol Chem 274:37809-37814, 1999.
  • Morris VL, Schmidt EE, Koop S, MacDonald IC, Gratten M, Khokha R, McLane MA, Niewiarowski S, Chambers AF, Groom AC. Effect of integrin expression on tumor cell migration during hematogenous metastasis. Exp Cell Res 219: 571-578, 1995.

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