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Huey-Jen Lin

Huey-Jen Lin, Ph.D.; MT(ASCP)

Associate Professor
Medical Laboratory Sciences
305 Willard Hall Education Building
302-831-7576
hlin@udel.edu

 

 

 

 

 

Education:

  • Ph.D.: University of Delaware, Newark, Delaware
  • Post-Doctoral Researcher: Princeton University, Princeton, New Jersey

Academic Appointments:

  • Research Faculty Member: Comprehensive Cancer Center, University of Michigan Medical Center; Ann Arbor, Michigan
  • Assistant Professor and Tenured Associate Professor: Comprehensive Cancer Center, Ohio State University Medical Center, Columbus, Ohio

Courses Taught:

  • Clinical Microbiology
  • Clinical Immunology
  • Molecular Diagnosis

Research Interest:

Examine how epigenetically silenced tumor suppressor genes influence tumor initiation, progression and metastasis in breast and pancreatic cancers. My long-term research objective is to examine how aberrant signaling molecules regulate epigenomes and lead to a wide spectrum of malignant phenotypes , primarily in breast and pancreatic cancers. The ultimate goals are: to identify the microenvironmental cause (s) leading to tumorigenesis, decipher how dysregulated signaling pathways contribute to neoplasm by altering epigenomes, discover potential diagnostic bio-markers, and develop specific therapeutic strategies by correcting signaling molecules.

Peer-reviewed research publications.

  • Wang F-F, Wang Y-J, Lee H-J, Fong J-C. Identification of erythropoietin receptors of erythroleukemic cells. Biochemistry International 18:163-171 (1989).
  • Lin H-J, Upson RH, Simmons DT. Nonspecific DNA binding activity of simian virus 40 large T antigen: evidence for the cooperation of two regions for full activity. Journal of Virology 66:5443-5452 (1992).
  • Lin H-J., Eviner V., Prendergast GC., White E. Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest. Mol Cell Biol. 15:4536-4544 (1995). PMID: 7623844.
  • Page C, Lin H-J*, Jing Y, Castle VP, Nuñez G, Lin J. Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis. Anticancer Research 20:407-16 (2000). *First two authors contributed equally to this work.
  • Lin H-J, Flint SJ. Identification of a cellular repressor of transcription of the adenoviral late Iva2 gene that is unaltered in activity in infected cells. Virology 277:397-410 (2000).
  • Lin H-J, Holman P, Lu J, Finniss S, Dickinson C and Castle VP. Functional activity of chimeric molecules containing a death signal against neuroblastoma. Clinical Cancer Research. 5 (11/99 suppl. #427) (2000).
  • Jasty R., van Golen C., Lin H-J., Solomon G., Heidelberger K., Polverini P., Opipari A., Feldman E., Castle VP. Bcl-2 and N-Myc coexpression increases IGF-IR and features of malignant growth in neuroblastoma cell lines. Neoplasia. 3:304-313 (2001). PMID: 11571630
  • Burke W., Jin X., Lin H-J., Huang M., Liu R., Reynolds RK., Lin J. Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells. Oncogene. 20:7925-7934 (2001). PMID: 11753675
  • Lin J., Jin X., Rothman K., Lin H-J., Tang H., and Burke W. Modulation of signal transducer and activator of transcription 3 activates by p53 tumor suppressor in breast cancer cells. Cancer Research. 62:376-380 (2002). PMID: 11809683
  • Bian X., Giordano TD., Lin H-J., Solomon G., Castle VP., Opipari AW. Jr. Chemotherapy-induced apoptosis of S-type neuroblastoma cells requires caspase-9 and is augmented by CD95/Fas stimulation. Journal of Biological Chemistry. 279:4663-4669 (2004). PMID: 14617634
  • Lin H-J.,* Hsieh FC., Song H., and Lin J. Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer. British Journal of Cancer (2005) 93:1372-1381. PMID: 16288304 *First and corresponding author.
  • Cen L., Arnoczky KJ., Hsieh FC., Lin H-J., Qualman SJ., Yu S., Xiang H., and Lin J. Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcoma. Modern Pathology, 20:936-946, (2007). PMID: 17585318
  • Cen L., Hsieh FC., Lin H-J., Chen CS., Qualman SJ., and Lin J. PDK-1/AKT pathway as a novel therapeutic target in rhabdomyosarcom cells using OSU-03012 compound. British Journal of Cancer 97, 785-791 (2007). (Nature Publishing Group). PMID: 17848913
  • Chan MW., Huang YW., Hartman-Frey C., Kuo C-T., Deatherage D., Qin H., Cheng AS., Yan PS., Davuluri RV., Huang TH., Nephew KP., and Lin H-J.* Aberrant Transforming Growth Factor-beta 1 Signaling and SMAD4 Nuclear Translocation Confer Epigenetic Repression of ADAM19 in Ovarian Cancer. Neoplasia 10:908-919. (2008). PMID: 18714391 *Corresponding author.
  • Lin H-J.,* Zuo T., Lin C-H., Kuo C-T., Liyanarachchi S., Sun S., Shen R., Deatherage DE., Potter D., Asamoto L., Lin S., Yan PS., Cheng A-L., Ostrowski MC., and Huang TH. Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells. Cancer Research 68:10257-10266 (2008). PMID: 19074894 *1st and corresponding author.
  • Chan C, Lin H-J, and Lin J. Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane. International Journal of Oncology 33:415-419 (2008).
  • Lieblein JC., Ball S., Hutzen B., Sasser AK., Lin H-J., Huang TH., Hall BM., Lin J. STAT3 can be activated through paracrine signaling in breast epithelial cells. BMC Cancer 21;8(1):302 (2008). PMID: 18939993
  • Qin H., Chan MW., Liyanarachchi S., Balch C., Potter D., Souriraj IJ., Cheng AS., Agosto-Perez FJ., Nikonova EV., Yan PS., Lin H-J., Nephew KP., Saltz JH., Showe LC., Huang TH., and Davuluri RV. An Integrative ChIP-chip and Gene Expression Profiling to Model SMAD Regulatory Modules. BMC Systems Biology 3:73 (2009). PMID: 19615063
  • Huang Y-W., Jansen RA., Fabbri E., Potter D., Liyanarachchi S., Chan MW., Liu JC., Crijns AP., Brown R., Nephew KP., van der Zee AG., Cohn DE., Yan PS., Huang TH., Lin H-J.* Identification of candidate epigenetic biomarkers for ovarian cancer detection. Oncology Reports 22:853-861 (2009). PMID: 19724865 *Corresponding author.
  • Chou J-L., Su H-Y., Chen L-Y., Liao YP., Hartman-Frey C., Lai YH., Yang H-W., Deatherage DE., Kuo C-T., Huang YW., Yan PS., Hsiao S-H., Tai CK., Lin H-J., Davuluri RV., Nephew KP., Huang TH., Lai H-C., Chan MW. Promoter hypermethylation of novel tumor suppressor FBXO32 predict survival in ovarian cancer patients. Lab Invest. 90(3):414-425 (2010). PMID: 20065949
  • Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, Zhou W, Benson DM Jr, Hofmainster C, Alder H, Garofalo M, Di Leva G, Volinia S, Lin H-J., Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM. Down-regulation of p53-inducible microRNAs 192, 194 and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell 18:367-381 (2010). PMID: 20951946
  • Zuo T, Liu TM, Lan X, Weng YI, Shen R, Gu F, Huang YW, Liyanarachchi S, Deatherage DE, Hsu PY, Taslim C, Ramaswamy B, Shapiro CL, Lin H-J., Cheng AS, Jin VX, Huang TH. Epigenetic Silencing Mediated Through Activated PI3K/AKT Signaling in Breast Cancer. Cancer Research 71(5):1752-1762 (2011). PMID: 21216892.
  • Lin L, Liu A, Peng Z, Lin H-J, Li P-K, Li C, and Lin J. STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. Cancer Research 71(23):7226-7237 (2011). PMID: 21900397. (IF: 8.206).
  • Peng Z, Weber JC, Han Z, Shen R, Zhou W, Scott J, Chan M, and Lin H-J. Dichotomy Effects of Akt/PKB signaling in breast cancer. Molecular Cancer 11:61 (2012).
  • Peng Z, Shen R, Li Y, Teng K-Y, and Lin H-J. Epigenetic Repression of RARRES1 Is Mediated by Methylation of a Critical Proximal Promoter Region Along with a Loss of CTCF Binding (PLoS One. 2012; 7(5): e36891).
  • Lin L, Hutzen B, Lee H-F, Peng Z, Lin H-J, Sun D, Li P-K, Li C, Korkaya H, Wicha M, and Lin J. STAT3 as a novel therapeutic target in human breast cancer initiating cells (submitted in 2012).

Book chapter publication.

  • 1. Alfred S.-L. Cheng, Huey-Jen Lin, and Tim H.-M. Huang. Book Chapter 6: Interrogating Estrogen Receptor a signaling in breast cancer by chromatin immunoprecipitation microArrays. Book Tile: Genomic Endocrinology. Editor: Stuart Handwerger and Bruce J. Aronow. (2008). ISBN: 978-1-58829-651-1.
  • Chan M, Peng Z, Weber JC, Li Y, Zuzolo N, and Lin H. Methods of Global Epigenomic Profiling. Book Title: Toxicoepigenomics. Editor: Saura C. Sahu, Ph.D.; Publisher: John Wiley and Sons Ltd (Published 2012).

Peer-evaluated review articles in journal:

  • Huey-Jen Lin*, Tao Zuo, Jennifer R. Chao, Zhengang Peng, Lisa Asamoto, Sonya Yamashita, and Tim H.-M. Huang. Seed in soil, with an epigenetic view. Biochimica et Biophysica Acta. 1790: 920-924 (2009). *1st and corresponding author. ISSN: 0304-419X.
  • Tao Zuo, Benjamin Tycko, Ta-Ming Liu, Huey-Jen Lin and Tim H.-M. Huang. Methods in DNA methylation profiling. Epigenomics 1(2):331-345 (In Press. ISSN 1750-1911; Publisher: Future Medicine).

Awarded Research grants (as the Principal Investigator in a chronological order)

  • Sponsor: American Cancer Society.
    Project title: Epigenetic influence of breast tumor-associated fibroblasts on normal mammary epithelia
  • Sponsor: US Army, Department of Defense, Idea grant award, Breast cancer research program.
    Project title: Epigenetic impact of breast tumor microenvironment on normal mammary stem cells. A Novel Approach for Developing Treatment Regimens and Diagnostic Tests.
  • Sponsor: Susan G. Komen for the cure grants program
    Project title: The epigenetic impact of cancer associated-fibroblasts on breast neoplasm.
  • Sponsor: Interdisciplinary Collaborative Grants, Comprehensive Cancer Center, The Ohio State University
    Project title: Epigenetic Influence of cancer-associated fibroblasts on pancreatic cancer initiation and progression


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