Daniel C. Flynn, PhD

Associate Dean of Research
Dean's Office
medical laboratory Sciences
205-C McDowell Hall
302-831-7578
dflynn@udel.edu

Research Interests

Our lab studies cell biology and focuses upon how kinases regulate cytoskeletal integrity. We discovered a protein called AFAP1, which is the prototype member of the AFAP family of proteins, as well as the related AFAP1L1 and our focus is upon understanding their molecular and cellular function, as well as their physiological role in normal development and health.

Our research has implications for Breast cancer and how this disease becomes invasive; as well as liver cancer.

Education/Certification

• 1977-1981 - University of Maryland, College Park B.S., Microbiology/Biochemistry
• 1982-1988 - North Carolina State University Ph.D., Microbiology/Virology
• 1988-1992 – Post-doctoral fellow, Dr. J. Thomas Parsons, University of Virginia. Identification of a Src binding partner, AFAP-110.

Professional Experience

• 1992-1998: Assistant Professor, Department of Microbiology & Immunology and the Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506
• 1998-2003: Associate Professor, Department of Microbiology & Immunology and the Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506
• 2000-2006: Associate Director for Basic Research, Mary Babb Randolph Cancer Center
• 2001-present Director, Center of Biomedical Research Excellence (CoBRE) for Signal Transduction and Cancer. West Virginia University Mary Babb Randolph Cancer Center
• 2001-present Founding scientist and Scientific Advisor, Protea Biosciences, Inc., Morgantown, WV
• 2003-2008. Professor, Mary Babb Randolph Cancer Center and the Dept. of Microbiology & Immunology, West Virginia University, Morgantown, WV 26506-9300.
• 2003-2008 Director, Cancer Cell Biology Research and Graduate Training Program, West Virginia University Health Sciences Center.
• 2006-2008 Deputy Director, Mary Babb Randolph Cancer Center, West Virginia University Health Sciences Center
• 2008-2012 Associate Dean for Research and Economic Development, Commonwealth Medical College, Scranton, PA
• 2012-present Associate Dean for Research, University of Delaware, College of Health Sciences

Recent Publications/Books & Publications

(of 67 publications)

• Xu, X., J. Harder, M, D.C. Flynn and L.M. Lanier. 2009. AFAP-120 regulates actin organization during neuronal differentiation. Differentiation 77:38-47. Epub 2008 Oct 16. PMID: 19281763
• Apopa PL, Qian Y, Shao R, Guo NL, Schwegler-Berry D, Pacurari M, Porter D, Shi X, Vallyathan V, Castranova V, Flynn DC. 2009. Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling. Part Fibre Toxicol. Jan 9;6:1. PMID: 19134195
• DA Clump, JJ Yu, Y Cho, R Gao, J Jett, H Zot, A Clump, M Shockey, P Gannett, J Coad, R Shurina, WD Figg, E Reed and DC Flynn. 2010. A polymorphic variant of AFAP-110 enhances cSrc activity. Translational Oncology, 3:276-285.
• B.Snyder, Y. Cho, Y. Qian, D.C. Flynn* and J. Cunnick*. 2011. AFAP1L1 is a Novel Adaptor Protein of the AFAP Family that Interacts with Cortactin and Localizes to Invadosomes. European Journal of Cell Biology 90:376-389. * Denotes equal communicating (senior) authors
• Khan SH, Ahmad F, Ahmad N, Flynn DC, and Kumar R. Protein-protein interactions: 2011. Principles, techniques, and their potential role in new drug development. J. Biomol. Struct. Dynamics 28:1-10.
• Reynold AB, Kanner SB, Bouton A, Weed S, Flynn DC, Parsons JT. 2013. Src substrates: 20 years later. Oncogene (in revision).

Grants

• 3R01-CA60731-15A1 Daniel C. Flynn (PI) 4/1/1994 - 6/30/2013 25%
  NIH/NCI $225,000/yr
• AFAP-110 effects actin filament integrity
  Goal: To determine the mechanism by which AFAP-110 alters actin filament integrity.

  Past funding: I have held program project grants, equipment grants and training grants from NIH and NSF; as well as private foundation grants for research.

Honors & Awards

• 1977-1981. Undergraduate Senatorial Scholarship. University of Maryland, College Park.
• 1989-1992. NIH post-doctoral training fellowship.
• 1993 Faculty Development Award, West Virginia University - Microinjection.
• 1995 Awarded “Blue Ribbon” for Outstanding Presentation in Signal Transduction; Poster/Discussion session; 86th annual meeting of the American Association for Cancer Research; Toronto, Ontario, Canada.
• 2001 Dean's Award for Excellence in Research - West Virginia University,
• 2005 Percival Maclachlan Award, Medical Educator Award, WVU School of Medicine.
• 2008 Percival Maclachlan Award, Medical Educator Award, WVU School of Medicine.
• 2009 CSR Award for Outstanding Service on NIH Study Sections.

Professional Membership

• American Association of Cancer Research (AACR): Full Member.
• American Society for Cell Biology (ASCB): Full Member, Serve on Membership Committee.
• American University Technology Managers (AUTM): Active member.
• American Association of Medical Colleges GRAND: Active Member
• NIH/NCI ONC-IRG study sections; 2001-present.

Courses

Careers in Health Sciences (planned)