William B. Farquhar

Chair & Associate Professor
Cardiovascular Research Laboratory
Kinesiology & Applied Physiology
143 Human Performance Lab
302-831-6178
wbf@udel.edu

Research Interests

• Cardiovascular Physiology
• Exercise Physiology

Education

• Post-Doc Beth Israel Deaconess Medical Center, Harvard Medical School, MA 2001, Integrative Physiology
• Ph.D Penn State University, PA 1998, Exercise Physiology
• M.S East Stroudsburg University, PA 1991, Cardiac Rehabilitation & Exercise Science
• BS East Stroudsburg University, PA , 1989, Exercise Physiology

Positions & Employment

• 1991-1992 Exercise Physiologist, Department of Cardiology, Easton Hospital, Easton, PA
• 1992-1994 Exercise Physiologist, Cardiac Rehabilitation Department, Lehigh Valley Hospital, Allentown, PA
• 1994-1998 Graduate Assistant, Department of Kinesiology, Penn State University, University Park, PA
• 1998-2001 Research Fellow (post-doc), Department of Neurology, BIDMC, Harvard Medical School, Boston, MA
• 2001-2002 Instructor in Medicine, Harvard Medical School Division on Aging, Boston, MA and Research Assistant Scientist, HRCA Research and Training Institute, Boston, MA
• 2002-2008 Assistant Professor, University of Delaware, College of Health Sciences, Department of Health, Nutrition and Exercise Sciences, Newark, DE
• 2008- Associate Professor, University of Delaware, College of Health Sciences, Department of Kinesiology and Applied Physiology, Newark, DE (joint appointments in Biology and Nursing)
• 2010- Faculty, Applied Physiology Graduate PhD Program, University of Delaware, Newark, DE
• 2004- Specified Health Professional (Research Privileges), Department of Medicine, Section of Cardiology, Christiana Care Health Services, Newark, DE
• 2007- DBI Affiliated Faculty, Delaware Biotechnology Institute, Newark, DE

Courses

• KAAP 433 Applied Physiology of Activity
• KAAP 603 Seminar in Exercise Science
• KAAP 655 Advanced Physiology of Exercise
• KAAP 615/BISC 605 Advanced Mammalian Physiology I

Other Experience & Professional Memberships

• 1995- Member, American Physiological Society
• 1991- Member, American College of Sports Medicine
• 2004- Fellow, American College of Sports Medicine
• 2006- Member, American Heart Association
• 2003- Editorial Board Member, Journal of Applied Physiology
• 2008- Editorial Board Member, Autonomic Neuroscience: Basic and Clinical
• 1998- ad hoc reviewer for several physiology and clinical journals
• 1996- Committee work for the American College of Sports Medicine (national and regional)
• 2004-5 NIH Office of Scientific Review – National Institute of General Medical Sciences Study Section, (outside reviewer)
• 2007 American Institute of Biological Sciences Program Review, United States Army Research Institute of Environmental Medicine (member, 4-person panel)
• 2008- Human Subjects Review Board (IRB), University of Delaware

Selected Peer-Reviewed Publications

• Kenney WL, Morgan AL, Farquhar WB, Brooks EM, Pierzga JM, and Derr JA. Decreased active vasodilator sensitivity in aged skin. Am J Physiol 272: H1609-1614, 1997.
• Farquhar WB and Kenney WL. Age and renal prostaglandin inhibition during exercise and heat stress. J Appl Physiol 86: 1936-1943, 1999.
• Farquhar WB, Morgan AL, Zambraski EJ, and Kenney WL. Effects of acetaminophen and ibuprofen on renal function in the stressed kidney. J Appl Physiol 86: 598-604, 1999.
• Farquhar W and Kenney L. Renal effects of ibuprofen during sodium restriction in the aged. J Am Geriatr Soc 48: 106-108, 2000.
• Farquhar WB, Taylor JA, Darling SE, Chase KP, and Freeman R. Abnormal Baroreflex Responses in Patients With Idiopathic Orthostatic Intolerance. Circulation 102: 3086-3091, 2000.
• Hunt BE, Fahy L, Farquhar WB, and Taylor JA. Quantification of mechanical and neural components of vagal baroreflex in humans. Hypertension 37: 1362-1368, 2001.
• Hunt BE, Farquhar WB, and Taylor JA. Does reduced vascular stiffening fully explain preserved cardiovagal baroreflex function in older, physically active men? Circulation 103: 2424-2427, 2001.
• Farquhar WB, Hunt BE, Taylor JA, Darling SE, and Freeman R. Blood volume and its relation to peak O(2) consumption and physical activity in patients with chronic fatigue. Am J Physiol Heart Circ Physiol 282: H66-H71, 2002.
• Freeman R, Lirofonis V, Farquhar WB, and Risk M. Limb venous compliance in patients with idiopathic orthostatic intolerance and postural tachycardia. J Appl Physiol 93: 636-644, 2002.
• Myers CW, Farquhar WB, Forman DE, Williams TD, Dierks DL, and Taylor JA. Carotid Distensibility Characterized via the Isometric Exercise Pressor Response. Am J Physiol Heart Circ Physiol, 283 (6): H2592-8, 2002.
• Pescatello LS, Franklin BA, Faggard R, Farquhar WB, Kelley GA, Ray CA. Exercise and Hypertension: American College of Sports Medicine Position Stand. Med. Sci. Sports Exerc. 36: 533-553; 2004.
• Hunt BE and Farquhar WB. Nonlinearities and Asymmetries of the Human Cardiovagal Baroreflex. Am J Physiol Regul Integr Comp Physiol, 288(5):R1339-46, 2005.
• Farquhar WB, Paul EE, Prettyman AV, Stillabower ME. Hemodynamic Responses to an Acute Sodium Load in Humans. J Appl Physiol 99: 1545-1551, 2005.
• Wenner MM, Prettyman AV, Maser RE, Farquhar WB. Preserved Autonomic Function in Amenorrheic Athletes. J Appl Physiol, 101 (2): 590-7, 2006.
• Farquhar WB, Wenner MM, Delaney EP, Prettyman AV, Stillabower ME. Sympathetic Neural Responses to Increased Osmolality in Humans. Am J Physiol Heart Circ Physiol, 291(5): H2181-6, 2006.
• Young CN, Stillabower ME, DeSabatino A, Farquhar WB. Venous Smooth Muscle Tone and Responsiveness in Older Adults. J Appl Physiol, 101(5):1362-7, 2006.
• Wenner MM, Delaney EP, Rose WC, Stillabower ME, Farquhar WB. The Influence of Plasma Osmolality on Baroreflex Control of Sympathetic Activity. Am J Physiol Heart Circ Physiol, Oct; 293(4): H2319-9, 2007.
• Young CN, Prasad RY, Fullenkamp AM, Stillabower ME, Farquhar WB, and Edwards DG. Ultrasound Assessment of popliteal vein compliance during a short deflation protocol. J Appl Physiol, May; 104(5): 1374-80, 2008.
• Delaney EP, Young CN, DiSabatino A, Stillabower ME, Farquhar WB. Limb venous tone and responsiveness in hypertensive humans. J Appl Physiol, Sep; 105(3): 894-901, 2008. PMCID: PMC2536820.
• Maser RE, Stabley JN, Lenhard MJ, Owusu-Griffin P, Provost-Craig MA, Farquhar WB. Zinc intake and biochemical markers of bone turnover in type 1 diabetes. Diabetes Care, Dec; 31(12): 2279-80, 2008.
• Reisman DS, Rudolph KS, Farquhar WB. Influence of speed on walking economy poststroke. Neurorehabil Neural Repair, Jul-Aug; 23(6):529-34, 2009.
• Sausen MT, Delaney EP, Stillabower ME, Farquhar WB. Enhanced metaboreflex sensitivity in hypertensive humans. Eur J Appl Physiol, Feb;105(3):351-6, 2009.
• Greaney JL, Ray CA, Prettyman AV, Edwards DG, Farquhar WB. Influence of increased plasma osmolality on sympathetic outflow during apnea. Am J Physiol Regul Integr Comp Physiol 2010 July 21 [Epub ahead of print].
• Delaney EP, Greaney JL, Edwards DG, Rose WC, Fadel PJ, and Farquhar WB. Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex. Am J Physiol Heart Circ Physiol, Nov;299(5):H1318-27, 2010. Epub 2010 Aug 27.
• Greaney JL, Farquhar WB. Why do veins stiffen with advancing age? J Appl Physiol. 2011 Jan;110(1):11-2. Epub 2010 Nov 4.
• Wenner MM, Edwards DG, Ray CA, Rose WC, Gardner TJ, Stillabower M, Farquhar WB. Celecoxib does not alter cardiovascular and renal function during dietary salt loading. Clin Exp Pharmacol Physiol. 2011 Jul; 38: 543-549. Epub 2011 Jun 1.

Ongoing Research Support

• 1 R01 HL104106-01A1 Farquahr (PI) and Edwards(PI) 09/07/2011- 06/30/2015
  NIH-NHLB
  Project Title: Vascular effects of dietary salt in humans with salt-resistant BP
  Role: Co-I

  The purpose of this project is to examine the effects of excess dietary salt on blood vessels in middle-aged adults with normal blood pressure.

• 5 R01 NR010786 Binder-Macleod (PI) 9/12/07 – 5/31/12
  NIH-NINR
  Project Title: Fast Treadmill Training/Functional Electrical Stimulation to Improve Walking Post Stroke
  Role: Co-I
  
  The overall goal of this project is to develop a physiologically based intervention to improve functional ambulation in individuals who have sustained a stroke.

Research Support: Completed (during the last 5 years)

• 2 P20 RR016472-08 Weir (PI) 5/1/09 – 4/30/12
  NIH-NCRR
  Overall Project Title: Delaware INBRE IDeA Network of Biomedical Research Excellence
  Role: Co-I (oversee subproject titled: Physiological Effects of Dietary Sodium in Salt Resistant Humans)
  
  The purpose of this subproject is to examine the effects of dietary salt on circadian blood pressure rhythm, arterial vascular function, and venous vascular function in a group of salt resistant humans. The goal of this subproject is to generate data for an NIH R01 submission.

• R15 HL074851-01 , -02 Farquhar (PI) 2/23/04 – 4/30/10
  National Heart, Lung, and Blood Institute
  Project Title: Sympathetic – Osmotic Interactions in Humans
  Role: PI
  
  The purpose of this project was to investigate the osmotic regulation of sympathetic nervous system activity in humans.
• R03 AG023836-01A1 Farquhar (PI) 1/01/05 – 12/31/06
  National Institute on Aging
  Project Title: Venous Hemodynamic Function in Older Hypertensive Adults
  Role: PI
  
  The purpose of this project was to investigate age- and disease-related differences in limb venous compliance and smooth muscle tone.
• AHA Proposal Reisman (PI) 7/1/07 – 6/30/09
  Project title: Relationship between speed and walking function following stroke
  Role: Co-I
  
  The goal of this project is to examine metabolic cost and overall economy of walking in patients that have suffered a stroke.
• 5 R01 HL071159-05 Stachenfeld (PI) 5/1/08 – 4/30/09
  NIH-NHLBI
  Project Title: Estrogen and Progesterone Effects on Orthostatic Tolerance
  Role: Co-I, oversee subcontract
  
  The purpose of this project is to determine the effects of estradiol and progesterone on sympathetic outflow and cardiovagal baroreflex function and to determine the effects of these hormones on peripheral blood flow in women with high and low orthostatic tolerance.