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David G. Edwards

David G. Edwards

Associate Professor
Vascular Physiology Laboratory
Kinesiology & Applied Physiology
201Q CHS Star Campus




Current Research

  • Cardiovascular physiology
  • Exercise Physiology


  • PhD, University of Florida, 2002
  • MS, Wake Forest University, 1993
  • BS, University of Delaware, 1991

Professional Experience

  • 1993-1994 Research Assistant, Health and Exercise Science, Wake Forest University

  • 1994-1995 Clinical Research Assistant, Corning Besselaar, Inc, Princeton, NJ

  • 1995-1997 Research Associate, Health and Exercise Science, Wake Forest University

  • 1998-2002 Graduate Assistant, Exercise and Sport Science, University of Florida

  • 2002-2005 Assistant Professor of Kinesiology, University of New Hampshire

  • 2005-2009 Assistant Professor, University of Delaware, College of Health Sciences, Department of Health, Nutrition and Exercise Sciences, Newark, DE

  • 2009- Associate Professor, University of Delaware, College of Health Sciences, Department of Kinesiology and Applied Physiology, Newark, DE (joint appointment in Biological Sciences)

  • 2010- Coordinator and Faculty, Applied Physiology Graduate PhD Program, University of Delaware, Newark, DE

  • 2006- Specified Health Professional (Research Privileges), Department of Medicine, Section of Cardiology, Christiana Care Health Services, Newark, DE

  • 2007- DBI Affiliated Faculty, Delaware Biotechnology Institute, Newark, DE

Courses Currently Teaching

  • HESC 310 Preclinical Anatomy and Physiology II
  • HESC 451 Clinical Exercise Physiology
  • HESC 654 Medical Physiology

Other Experience and Professional Memberships

  • 1995- Member, American Physiological Society
  • 1991- Member, American College of Sports Medicine
  • 2009- Editorial Board Member, Journal of Applied Physiology

Honors and Awards

  • 2005 Kent B. Pandolf/USARIEM New England ACSM Young Investigator Award

Selected Peer Review Publications

  • Braith RW, Edwards DG. Exercise following heart transplantation. Sports Med 2000; 30:171-92.
  • Braith RW, Howard C, Fricker FJ, Mitchell M, Edwards DG. Glucocorticoid-induced osteopenia in adolescent heart transplant recipients. J Heart Lung Transplant 2000; 19:840-845.
  • Nichols WW, Edwards DG. Arterial elastance and wave reflection augmentation of systolic blood pressure: deleterious effects and implications for therapy. J Cardiovasc Pharmacol Ther 2001; 6:5-21
  • Schofield RS, Schuler BT, Edwards DG, Aranda JM, Hill JA, Nichols WW. Amplitude and timing of central aortic pressure wave reflections in heart transplant recipients Am J Hypertens 2002; 15:809-815
  • Braith RW, Edwards DG. Endurance exercise training reverses neurohormonal abnormalities in heart failure. Congest Heart Fail 2003; 9:70-76.
  • Schofield RS, Edwards DG, Schuler BT, Estrada J, Aranda JM, Pauly DF, Hill JA, Aggarwal R, Nichols WW. Vascular effects of sildenafil in hypertensive cardiac transplant recipients. Am J Hypertens 2003 Oct; 16:874-7.
  • Edwards DG, Schofield RS, Lennon SL, Pierce GL, Nichols WW, Braith RW. Effect of exercise training on endothelial function in men with coronary artery disease. Am J Cardiol, 2004; 93:617-20.
  • Edwards DG, Schofield RS, Magyari PM, Nichols WW, Braith RW. Effect of exercise training on central aortic pressure wave reflection in coronary artery disease. Am J Hypertens, 2004; 17: 540-543.
  • Braith RW, Magyari PM, Pierce GL, Edwards DG, Hill JA, White LJ, Aranda JM. Effect of resistance exercise on skeletal muscle myopathy in heart transplant recipients. Am J Cardiol 2005; 15: 1192-1198.
  • Edwards DG, Lang JT. Augmentation index and systolic load are lower in competitive endurance athletes. Am J Hypertens, 2005; 18: 679-683.
  • Edwards DG, Gauthier al, Hayman MA, Lang JT, Kenefick RW. Acute effects of cold exposure on central aortic wave reflection. J Appl Physiol 2006; 100:1210-1214.
  • Pierce GL, Magyari PM, Aranda JM, Edwards DG, Hamlin SA, Hill JA, Braith RW. Effect of heart transplantation on skeletal muscle metabolic reserve and fiber-type in end-stage heart failure patients. Clin Transplant 2007; 21:94-100.
  • Heffernan KS, Jae SY, Edwards DG, Kelly EE, Fernhall B. Arterial Stiffness Following Repeated Valsalva Maneuvers and Resistance Exercise in Young Men. Appl Physiol Nutr Metab 2007;32:257-264.
  • Heffernan KS, Edwards DG, Rossow L, Jae SY, Fernhall B. Mechanical compression reduces regional arterial stiffness. Eur J Appl Physiol 2007; 101:735-741.
  • Edwards DG, Mastin C, Kenefick RW. Wave reflection and central aortic pressure responses to static and dynamic muscle contraction at comparable workloads. J Appl Physiol 2008; 104:439-445.
  • Young, CN, Prasad RY, Fullenkamp AM, Stillabower ME, Farquhar WB, Edwards DG. Ultrasound assessment of politeal vein compliance during a short deflation protocol. J Appl Physiol 2008; 104 1374-1380.
  • Edwards DG, Roy MS, Prasad RY. Wave reflection augments central systolic and pulse pressures during facial cooling. Am J Physiol Heart 2008; 294:2535-2539.
  • Greaney JL, Ray CA, Prettyman AV, Edwards DG, Farquhar WB. Influence of increased plasma osmolality on sympathetic outflow during apnea. Am J Physiol Regul Integr Comp Physiol, 2010; 299: R1091-6, 2010.
  • Delaney EP, Greaney JL, Edwards DG, Rose WC, Fadel PJ, Farquhar WB. Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex. Am J Physiol Heart Circ Physiol, 2010 299: H1318-27.

Ongoing Research

  • 2 P20 RR016472-08
    Weir (PI)
    5/1/09 – 4/30/12

    Overall Project Title: Delaware INBRE IDeA Network of Biomedical Research Excellence

    Role: Co-I overseeing subproject titled: Endothelial Function in Chronic Kidney Disease
    The purpose of this subproject is to provide support to gather preliminary data in support of an NIH R01 submission. The 5/6 ablation/infarction rat model is being used to investigate mechanisms of vascular dysfunction in chronic kidney disease.

    Role: Collaborator for subproject titled: Physiological Effects of Dietary Sodium in Salt Resistant Humans

    The purpose of this subproject is to provide support to gather preliminary data in support of an NIH R01 submission. The preliminary data collected has been to examine the effects of dietary salt on arterial vascular function.

  • 1 R15 DK080469-01
    Edwards (PI)
    Project Title: Microvascular Function in Chronic Kidney Disease

    Role: PI
    The goal of this study is to determine the mechanisms of microvasular dysfunction in chronic kidney disease by studying nitric oxide mediated cutaneous vasodilation in response to local heating using laser Doppler and cutaneous microdialysis.

Research Support: Completed (during the last 3 years)

5 R21 DK077306-02
Edwards (PI)

Project Title: Oxidative Stress and Vascular Function in Chronic Kidney Disease

Role: PI
The goal of this recently completed study was to determine if oxidative stress is a mechanism of impaired endothelial function (brachial artery flow mediated) dilation in chronic kidney disease.

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