CHEM-642 Biochemistry
Tentative Schedule  -  Spring 2002

Meeting Time and Place: Section 10 meets  3:30 to 4:45 PM Tuesdays and Thursdays in 004 Drake Laboratory. Section 11 meets 9:30 to 10:45 AM Tuesdays and Thursdays in 205 Brown Laboratory. Because morning and evening lectures will be presented by the same professor and because there will be common hourly and final examinations for both sections, students may attend either or both lectures providing seats are available in the small lecture room (004 QDH). The first half of the course (through March 21) will be taught by Prof. Hal White and the second half (starting March 26) by Prof. Junghuei Chen. Text chapters and sections in parentheses refer to Garrett and Grisham's, BiochemistryCopies of the overheads used by Dr. Chen will be on reserve in the Chemistry Library in Brown Laboratory after Spring Break.
 

Tuesdays 9:30-10:45 AM & 3:30-4:45 PM Thursdays 9:30-10:45 AM & 3:30-4:45 PM
February 5
Introduction and Review of Metabolic Principles 
       (Chapter 18.1-18.3)
February 7
Glycogen Synthesis and Degradation 
       (Chapter 23.3 - 23.5) 
Lactose Metabolism
February 12
Pentose Phosphate Pathway  (Chapter 23.6)
NAD vs NADP in redox reactions
Introduction to Fatty Acid structure and nomenclature
Problem Set 1 due
February 14
Oxidation of Odd-Chain Length and 
       Unsaturated Fatty Acids
       (Chapter 8) Biosynthesis of Lipids (Chapter 25) 
Propionyl CoA Metabolism and B12
Glycerides

Membranes & Selected Topics 
       (Chapters 9 & 10)

February 19
Ketone Body Metabolism (Chapter 24.3-24.6)
Citrate-pyruvate Cycle
Comparison of Fatty Acid Synthesis and Degradation
Problem Set 2 due
February 21

Lipid Metabolism cont. 
Glyceride Metabolism 
Overview of Signal Transduction
(Chapters 9, 10, and 25) 
Cholesterol and isoprenoid Biosynthesis
 

February 26
Principle of self organization
Lipid Membranes
Problem Set 3 due
February 28 
Nitrogen Acquisition and Excretion 
        (Chapter 26) 
Amino Acid Metabolism 
March 5
Amino Acid Metabolism cont. (Chapter 26) 
Problem Set 4 due
March 7
Amino Acid Metabolism cont. (Chapter 26)
First Hour Exam Saturday March 9, 
10 AM - noon in 205 Brown Laboratory.
March 12
Integration of Energy Metabolism, Starvation 
March 14
Integration of Energy Metabolism, Athletic Performance
March 19
Overview of Nucleotide Metabolism 
         (Chapters 11 & 27) 
March 21
Introduction to Molecular Biology
March 26  (Dr. Chen begins lecturing) 
Structure and Function of DNA, History of the experiments showing DNA is the Genetic material.
March 28 
Properties of DNA, Secondary structure, Supercoiling and linking numbers
April 3
SPRING BREAK
April 5
SPRING BREAK
April 9
Topoisomerases, DNA packing, Chromosome structure.
April 11
DNA replication in prokaryotes and eukaryotes, 
Central Dogma
April 16
Primosomes and Replisomes, DNA polymersaes, Mechanism of replication
April 18
Eukaryotic replication, "Reverse transcriptase," 
Mutation and DNA repair
April 23
DNA repair continued, Recombination and its enzymology.
April 25
Recombination continued, Immunoglobulin somatic recombination,  Lambda phage, Transposons.
April 30
Transcription, RNA Polymerase, Transcription Regulation in prokaryotes, Lac operon.
May 2
Transcription factors and termination in eukaryotes, RNA Processing, Catabolite activation
Second Hour Exam based on Dr. Chen's lectures on Saturday, May 4 from 10 - noon in 101 Brown Laboratory 
May 7
Translation
May 9
Translation continued 
May 14
Recombinant DNA methodology
Final Comprehensive Examination
Three hour examination scheduled during Finals Week.



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Last updated 5 March 2002 by Hal White.
Copyright 2002, Harold B. White, Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716