HHMI
Undergraduate Research Scholars
Talks & Poster Presentations
Spring 2001
Talks and Poster presentations from the following events:
American Society for Biochemistry and Molecular Biology Meetings,
30 March 2001, Orlando, Florida.

2001 Undergraduate Research Scholars Poster Session,
27 April 2001, Trabant University Center

16th Annual Undergraduate Research Symposium,
5 May 2001, Perkins Student Center

Nicole Goodwin, Chemistry Laura Tolen, Biochemistry Allison Olszewski, Biochemistry
Isaac Hubner, Biochemistry Susan Biehn, Biology Kathryn Payne, Biology
Jacob LaPorte, Biochemistry Jennifer Crocco, Biochemistry Jaimie Robinson, Biochemistry
Jennifer Leszl, Biology Justin DiAngelo, Biology Kelly Sewell, Biology
Laura Maliszewski, Biology Eric Evans, Biology Michael Usher, Biology
Cory Ocasio, Biochemistry John Heiss, Biochemistry Laura Vella, Biology
Kathryn O'Reilly, Biochemistry Melissa Kuchar
Medical Technology
Kathryn Whitehead
Chemical Engineering
Jennifer Rutan, Biology Franchita Lockwood, Biology Eric Pridgen, Chemical Engineering
Michael Scoblete, Biochemistry 
and Chemical Education



 
Scholar:  Suzanne Biehn

Major:  Biology
Research Mentor:  Norman Karin, Department of Biological Sciences

Poster Title: Induction of Endoplasmic reticulum Biogenesis


 
Scholar:  Jennifer Crocco

Major:  Biochemistry
Research Mentor:  Roberta Colman, Department of Chemistry and Biochemistry
Project Title:  Mechanism of Adenylate Synthetase

Poster & Abstracts: Jennifer M. Crocco, Jennifer L. Brosius, and Roberta F. Colman. Characterization of 2 Bacillus subtilis Adenylosuccinate Lyases Equivalent to Mutations Found in Human Adenylosuccinate Lyase Deficiency. ASBMB Meeting, Orlando, FL. April 2001. FASEB J 15(4) A187 (2001) Abst. 184.19

Jennifer L. Brosius, Jennifer M. Crocco, Roberta F. Colman. Three subunits contribute Critical Amino Acids to the Active Site of Tetrameric Adenylosuccinate Lyase. FASEB J 15(4) A187 (2001) Abst. 184.18
 


 
Scholar:  Justin DiAngelo

Major:  Biology
Research Mentor:   Melinda Duncan, Department of Biological Science
Project Title:  Function  of Bves in Heart Development, Purification using a His Tag.

Poster & Abstract: JR DiAngelo, TK Vasavada, MK Duncan. Expression of an Intractable Protein in E. coli. Sigma Xi Undergraduate Research Day at Thomas Jefferson University, 2001 (First Prize)
Awards and Honors: Membership in Golden Key National Honors Society, Phi Kappa Phi, National Honors Society, Honors Degree with Distinction Candidate.


 
Scholar:  Eric Evans

Major:  Biology

Research Mentor:  Patricia DeLeon, Department of Biological Sciences .

Project Title: Epididymal SPAM1 Expression in Humans

Awards and Honors: Phi Beta Kappa Clift and DeArmond Award, Phi Kappa Phi, Degree with Distinction Candidate
 


 
Scholar:  Nicole Goodwin
Major: Chemistry
Research Mentor: Douglass Taber
Thesis Title: Synthesis of (+)-3--Oxo-a-Cadinol: A New Development in Alkylidene Carbene Insertion.
Presentations: 64th Annual Intercollegiate Student Chemists' Conference, Bloomsburg University, 15 April 2000.
65th Annual Intercollegiate Student Chemists Conference, Goucher College, 21 April 2001 
Philadelphia Organic Chemists Convention, University of Pennsylvania, 31 may 2001.
Honors and Awards:  American Chemical Society Delaware Section Scholarship, Quaesita Drake Scholarship, HHMI Undergraduate Research Scholar, Phi Beta Kappa, Phi Kappa Phi, James A. Moore Undergraduate Award in Organic Chemistry.
Other Activities: UD Marching and Pep Bands, Blue Hen Ambassador, Spirit Ambassador, Teaching Assistant for CHEM-111H&112H, Laboratory Assistant CHEM-322.
After Graduation: Doctoral Program in Organic Chemistry at Cal Tech

 
Scholar:  John Heiss

Major:  Biochemistry
Research Mentor:  Brian Bahnson, Department of Chemistry and Biochemistry
Project Title:  X-Ray Structure of Tyrosine Phosphatase

Poster Title: Crystallization and X-ray Crystallography of Protein Tyrosine Phosphatase


 
Isaac Hubner

Major: Biochemistry

Research Mentor:  Douglas Doren
Thesis Title: Computational Inquiries on the Chemical Functions of a Silicon Surface
Presentations: 64th Annual Intercollegiate Student Chemists' Conference, Bloomsburg University, 15 April 2000 
65th Annual Intercollegiate Student Chemists Conference, Goucher College, 21 April 2001
Honors and Awards: Phi Beta Kappa, HHMI Undergraduate Research Scholar. Study Abroad Program at Imperial College London, UK., Alumni Association Achievement Award Scholarship, American Institute of Chemists Award in Chemistry, James A. Moore Undergraduate Award in Organic Chemistry.

After Graduation: Doctoral Program in Theoretical Chemistry at Harvard University. Awarded an HHMI Graduate Fellowship


 
Scholar: Michelle Denise Lazarus

Major: Biology

Research Mentor: Gary Laverty, Biology

Thesis Title: Ammonia Transport in Avian Proximal Convoluted Tubule on Primary Cell Culture Models

After Graduation: Doctoral program in Cell Biology at Thomas Jefferson Medical College


 
Scholar:  Jennifer Leszl

Major:  Biology

Research Mentor: David Usher, Department of Biological Sciences

Project Title:  Catabolism of Turtle HDL, SAGE Analysis of Gene Expression


 
Scholar:  Melissa Kuchar

Major:  Medical Technology
Research Mentor:  Mary Ann McLane, Department of Medical Technology
Project Title:  Eristostatin Inhibition of Melanoma Metastasis
Honors and Awards: Phi Kappa Phi, Phi Kappa Phi Undergraduate Research Essay and Research-in-Progress Essay Awards.
Poster & Abstracts: McLane MA, Kuchar MA, Paquette CA, Miele ME. Critical amino acids involved in interactions between eristostatin and human melanoma cells.  Mol Biol Cell 11: 263A, poster abstract 1371, 2000. (presented at the ASCB meeting, December 2000)

McLane MA, Brando C, Paquette C. Kuchar M, Miele ME. New insights on disintegrin-receptor interactions.  Submitted for International Conference on Exogenous Factors affecting Thrombosis and Haemostasis (invited speaker), July 12-13, 2001, Paris France.

Melissa Kuchar, Carrie Paquette, Mary Ann McLane. 
Molecular Mechanisms Used in Eristostatin's Inhibition of Metastasis, at the ASBMB Meetings Orlando, FL. April 2001FASEB J 15: A179, poster abstract 180.8, 2001.


 
Scholar:  Jacob LaPorte

Major:  Biochemistry
Research Mentor:  Junghuei Chen, Department of Chemistry and Biochemistry
Project Title:  Elucidating the Role of DNA Aggegates in the Homologous Recombination Strand Exchange  Reaction

Honors and Awards: Elected to Mortar Board
Publications: Zhaoquin Zhang, Dennis Yoon, Jacob R. LaPorte, and Junghuei Chen, Appropriate Initiation of Strand Exchange Reaction Promoted by RecA Protein Requires ATP Hydrolysis. J.Mol. Biol.  309, 29-43 (2001)

After Graduation: Doctoral Program in Chemistry at Harvard University, Awarded an HHMI graduate Fellowship


 
Scholar:  Franchita Lockwood

Major:  Biology
Research Mentor:  Patricia DeLeon, Department of Biological Sciences 

Poster Title:  A Comparison of the Regionalization of Spam1on the Surface of ICR an Rb(6.16) Mice Sperm During Epididymal Maturation.

 


 
Scholar: Laura Maliszewski

Major:  Biology with concentration in Biotechnology
Research Mentor: Allan Shapiro, Department of Plant and Soil Science
Project Title: A Screen for Mutants give Programmed Cell Death in
Arabidopsis despite Chemical Inhibition of Nitric Oxide Synthase. 

Abstracts:
Worley, C.K., Maliszewski, L.E., Hubner, J.H. and Shapiro, A. D., "Genetic Screen to Identify Arabidopsis Mutants Which Overcome a Nitric Oxide Synthase Inhibitor Block of the Hypersensitive Response" 11th International Conference on Arabidopsis Research, Madison, WI, 2000. 

Worley, C.K., Maliszewski, L.E., Hubner, J.H., Farnworth, B., Yang, H.-Y. and Shapiro, A. D., "hdn (HR Despite NOS inhibitor) Mutants Identify Multiple Controls over Arabidopsis Programmed Cell Death" 12th International Conference on Arabidopsis Research and at the 10th International Congress on Molecular Plant-MicrobeInteractions, Madison, WI, 2001. 

After Graduation: Doctoral Program in Virology at Harvard Medical School


 
Cory Ocasio

Major: Biochemistry
Minor: Biology
Research Mentor: John Koh
Thesis Title: Mutant Human Vitamin D Receptor Induced Transcription Mediated by Custom-Designed Analogs of a Vitamin D Mimic.
Presentations: 16th Annual Undergraduate Research Symposium.
Honors and Awards: Phi Beta Kappa, Phi Kappa Phi, American Chemical Society Scholarship, Merck Index Award, Ronald E. McNair Post Baccalaureate Achievement Program, DuPont Pharmaceutical Company Summer Internship Program (3 summers), NUCLEUS Senior Award.

After Graduation: Graduate Program in Chemistry and Chemical Biology at the University of California, San Francisco


 
Scholar:  Allison Olszewski

Major:  Biochemistry

Research Mentor:  John Koh, Department of Chemistry and Biochemistry

Poster Title:  Semi-synthesis of a Novel Transcription Regulator
 


 
Scholar:  Kathryn O'Reilly 

Majors:  BS Biochemistry, BA French
Research Mentor: John Koh, Department of Chemistry and Biochemistry
Thesis Title:  Novel Ligand-Dependent Control of Transcription Pathways.
Presentation: Second Place Biochemistry Division, 64th Annual Intercollegiate Student Chemists' Conference, Bloomsburg University, 15 April 2000.
Honors and Awards: Kevin Beale Award for outstanding CHEM/BIOCHEM freshman, Phi Beta Kappa Clift and DeArmond Award for an outstanding freshman,  Phi Kappa Phi, Phi Beta Kappa, Phi Delta Pi (French Honor Society), Alpha Lambda Delta, Advanced Honors Certificate, American Chemical Society Award to the outstanding junior in chemistry or biochemistry. HHMI Undergraduate Reseach Scholar.
Publications:  Hai Fen Ye, John T. Koh, and Kathryn E. O'Reilly, A subtype-selective thyromimetic designed to bind a mutant thyroid hormone receptor implicated in resistance to thyroid hormone (RTH)., J. Am. Chem. Soc., 2001, 123, 1521-1522.  (Featured in C&E News, 79(9), 37, SCIENCE CONCENTRATES, February 26, 2001)
After Graduation: MD-PhD Program at Cornell Medical School


 
Scholar: Kathryn Payne

Major:  Biology

Research Mentor:  Malcolm Taylor, Department of Biological Sciences

Poster Title:   Ovarian Contraction  in Fundulus Ovary
 


 
Scholar:  Eric Pridgen

Major:  Chemical Engineering

Research Mentor:  Anne Skaja Robinson, Department of Chemical Engineering

Poster Title:  The Unfolded Protein Response During Heterologous Protein Expression in Saccharomyces cerevisiae


 
Scholar:  Jaimie Robinson

Major:   Biochemistry

Research Mentor:  Eugene Mueller, Department of Chemistry and Biochemistry

Project Title:  Site-Specific Incorporation of 4-thiouridine into RNA

Poster & Abstract: Jamie S. Robinson and Eugene G. Mueller, Will introduction of an E.coli gene lead to 4-thiouridine in yeast? ASBMB Meeting, Orlando, FL. April 2001.


 
Scholar:  Jennifer Rutan

Major:  Biotechnology Minors: History and Chemistry
Research Mentor: Robert Hodson. Department of Biological Sciences
Project Title:   Characterization of 38kD Apolipoprotein DNA in the Turtle, Pseudemeyes scripta.
Honors and Awards: Elected to Mortar Board,  Phi Beta Kappa, Phi Kappa Phi, Recipient of the Phi Kappa Phi (University of Delaware Chapter) Graduate, Fellowship,  Mortar Board, Honors Degree with Distinction.
Poster & Abstract:Jennifer Rutan, Michael Usher, Matthew Russell, Robin Davis, Shui Quig Ye, Gregory Stephens, Robert Hodson, and David Usher. Conservation of the Apolipoprotein AI-CIII Linkage Group in Reptiles. ASBMB Meetings, Orlando, FL. April 2001.
FASEB J 15(4) A195 (2001) Abst 188.5
After Graduation: Doctoral Program University of North Carolina at Chapel Hill


 
Scholar:  Michael Scoblete

Major:  Chemistry
Research Mentor:  Klaus Theopold, Department of Chemistry and Biochemistry
Project Title:  Iron-Coordinating Complexes that Bind and Cleave Dioxygen

Presentations: 64th Annual Intercollegiate Student Chemistsí Conference, 15 April 2000, Bloomsburg University, Bloomsburg, Pennsylvania. 

33rd Middle Atlantic Regional Meeting of the American Chemical Society, 16 May 2000, Newark, Delaware. 

After Graduation: Teaching High School Chemistry in New Jersey
 


 
Scholar:  Kelly Sewell

Major:  Biology
Research Mentor:  David Usher, Department of Biological Sciences

Poster Title: Screening of a 27kd Apolipoprotein


 
Laura Tolen

Major: Biochemistry
Thesis Title: Attempt to Induce Autoimmunity to Riboflaviin-Binding Protein in Chickens.
Research Mentor:  Harold B. White
Presentations: 65th Annual Intercollegiate Student Chemists Conference, Goucher College, 21 April 2001
Honors and Awards: Quaesita Drake Scholarship, Phi Beta Kappa, Phi Kappa Phi
Activities: President, American Chemistry Society Student Affiliate Chapter
After Graduation: Doctoral Pharmacy Program, University of Maryland


 
Scholar:  Michael Usher

Major:  Biology
Research Mentor:  Eric Kmiec, Department of Biological Sciences
Project Title:  Gene Repair Model for Introducing Point Mutations

Posters & Abstracts: Michael Usher, Howard Gamper, Eric Kmeic. Targeting of a Chimeric Oligonucleotide to dsDNA for Site-Specific Gene Repair. ASBMB Meetings, Orlando, FL. April 2001. FASEB J 15(4), A518 (2001) Abst 435.2

Jennifer Rutan, Michael Usher, Matthew Russell, Robin Davis, Shui Quig Ye, Gregory Stephens, Robert Hodson, David Usher. Conservation of the Apolipoprotein AI-CIII Linkage Group in Reptiles. ASBMB Meetings, Orlando, FL. April 2001. FASEB J 15(4) A195 (2001) Abst 188.5


 
Scholar:  Laura Vella

Major:  Biology

Research Mentor:  Diane Herson, Department of Biological Sciences
Honors and Awards: Summer 2001 Research Fellowship from the American Society for Microbiology

Poster Title: Persistence of Helicobacter pylori


 
Scholar:  Kathryn Whitehead

Major:  Chemical Engineering
Research Mentor:  Anne Skaja Robinson, Department of Chemical Engineering

Poster Title:   Monitoring Aggregation of the P22 Tailspike Protein Through Size-Exclusion Chromatography

Awards and Scholarships: Chemical Engineering First Year Award, First Year Honors Certificate, UD Scholar Award, The Bunnell Scholarship, Just Born Candies Award,  World War II Alumni Award, Honors Program Scholarship, Chemical Engineering Class of 1950 Award, Engineering Teaching Assistant Award.


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Created 5 May 2001, Last modified 28 May 2001 by Hal White
Copyright 2001 Harold B. White, Department of Chemistry and Biochemistry, University of Delaware