CHEM-647 
BIOCHEMICAL EVOLUTION
Tentative Schedule
Fall Semester 2002

Amino acid conservation 
and replacement in Cytochrome c
R. E. Dickerson Sci. Am. 226(4):59 (1972)
Monday
Wednesday
 Friday
Sept 2  Labor Day Sept 4
Introduction to course.
Darwin's Theory
Sept 6
Begin Human Ancestry Assignment-Roots
Sept 9
Report back
Sept 11*
Wrap up Human Ancestry Problem
Sept 13 
Begin Case Study No. 1:
Fugu, Poison Frogs, and Pitohuis
 Sept 16
Case Study No. 1 continued
Sept 18
Case Study No. 1 continued
Sept 20
Case Study No. 1 continued
Sept 23*
Wrap up Case Study 1
Sept 25
Begin Case Study No. 2:
Aerial Ancestors?
Pg 1: Blood Brothers
Sept 27
Case Study No. 2: Aerial Ancestors?
Pg 2: Using Hemoglobin to Track Blood Lines
Sept 30
Case Study No. 2: Aerial Ancestors?  Pg 3: Reliability of Molecular Phylogenies
Oct 2
Case Study No. 2 Continued
Oct 4
Case Study No. 2 Continued
Oct 7*
Wrap up Case Study 2
Oct 9
Begin Case Study No. 3: Dating Eve. Pg 1: Dating is Never Easy
(Visitors for PBL Observation Day)
Oct 11*
Case Study No. 3: Dating Eve
Pg 2: Falling Out and Reconciliation
Oct 14
Case Study No. 3 Continued
Oct 16
Case Study No. 3 Continued
Oct 18*
No Class - Turn in assignments in Dr. White's Mailbox
Oct 21
Wrap up Case Study 3
Begin Case Study No. 4: Feverishly Evolving Antigens. 
Pg 1: The Black Death
Pg 2: A World of Different People
Oct 23
Midterm Evaluations Due
Case Study No. 4: Feverishly Evolving Antigens. 
Pg 3: Molecular Warfare 
Oct 25 
Work on Case Study 4 Group Assignment
Oct 28
Wrap up Case Study No. 4
Oct 30
No Class - Work on Your Case Study Concept Map
Nov 1*
Begin Case Study No. 5: 
The Eyes Have It
Pg 1: Visualizing Lactate Dehydrogenase
Nov 4*
Concept Map of Case Study Topic Due.
Case Study No. 5: The Eyes Have It
Pg 2: Corrective Lenses
Nov 6
Case Study No. 5: The Eyes Have It
Pg 3: Looking to the Future
Nov 8
Case Study No. 5 Continued
Nov 11*
Wrap up Case Study 5
Nov 13
Begin Case Study No. 6: 
Selective Neutrality
Pg 1: And the Bands Played On
Nov 15
No Class
Nov 18
Case Study No. 6: Selective Neutrality
Pg 2: Sense and Nonsense
Nov 20
Case Study No. 6: Selective Neutrality
Pg 3: Making Sense of Bias
Nov 22
Case Study No. 6 Continued
Nov 25*
Wrap up Case Study No. 6 
Nov 27
Group activity with wireless laptops as a prelude to the final group project
Nov 29 
Thanksgiving Break, No Class
Dec 2*
Case Study Due
Begin Final Group Project
Special Seminar at 4PM
Dec 4
Work on Group Project
Dec 6
Work on Group Project
Dec 9
Work on Group Project
Dec 11*
Group Final Projects Due
Course Wrap up
Final Course Evaluation
Schedule 1 Hour Final Interviews
Between December 4 and 13.
 * Assignments due on these dates.

Important Dates:
Friday, October 11 - Last Day to select a case study topic.
Monday, November 4 - Concept Map for Case Study Topic is due.
Monday, December 2 - Special Seminar "Exploring RNA and Protein Sequence Space by Directed Evolution" by Jack Szostak at 4 PM in 214 Brown Laboratory.



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Created 3 August 2002. Last updated 10 December 2002 by Hal White
Copyright 2002, Harold B. White, Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716