CHEM-643
INTERMEDIARY METABOLISM
Tentative Schedule
FALL SEMESTER 2013

The class meets Monday, Wednesday, and Friday from 9:05 to 9:55 AM in 205 Brown Laboratory.

Monday
Wednesday
Friday 

August 28
Intro. and Review of Metabolic Principles

August 30
ATP and Bioenergetics   
Energy Charge, and Adenylate Metabolism.
September 2
Labor Day - Holiday
September 4
Form Groups, Group work on metabolic reactions involving pyruvate.
September 6
Inborn Errors of Metabolism - Assignment due
Review of Pyruvate Pyruvate metabolism, Pyruvate dehydrogenase and its coenzymes
September 9
Lactose structure and metabolism
Pentose Phosphate Pathway  (oxidative branch)
September 11
Pentose Phosphate Pathway  (non-oxidative branch) 
NAD vs NADP in Redox Reactions

September 13
Review of Carbohydrate Metabolism
- Problems due

Life Without Oxygen problem for groups in class
Page 1, 2, 2a, 2b

September 16
Go over Homework Problem set 2
Wrap up Life Without Oxygen problem, 3, Summary
September 18
Are you what you eat?  Page 1
Read text chapter on Photosynthesis for Friday
Calvin-Benson Cycle Intermediates-cutout
Calvin Cycle
September 20
Are you what you eat? Page 2
September 23
Are you what you eat? Page 3 & 4
September 25
Are you what you eat? Page 5
September 27
Concluding Discussions, Summary
September 30
Group quiz on Glycolysis and Photosynthesis

October 2
Intro to Fatty Acid Structure and Nomenclature
Fatty acid oxidation
Fatty Acid Synthesis vs Degradation
Coenzyme A structure and function
October 4
Ketone Body Metabolism
Propionyl CoA Metabolism
Coenzyme B12
Lipid Metabolism - Problems  due
October 7
Citrate-pyruvate Cycle
Glyceride Metabolism
October 9
Steroid and Isoprenoid Biosynthesis
Overview of Isoprenoid metabolism
HMG-CoA and IPP synthesis
October 11
Rxns of HMGCoA - Problem due
Wrap up lipid metabolism
The Nitrogen Cycle
Intorduction to nitrogen fixation
October 14
Conceptual Class Activity on Modular assembly and self assembly in biosynthesis
October 16
Nitrogenase
Nitrate and Nitrite Reduction
Molybdopterin 
Intro. Amino Acid Metabolism
Nitrogen Acquisition and Excretion
October 18
Lysine Biosynthesis - Problem due
Ammonium entry into metabolism
Glutamine Synthetase and its Regulation
Pyridoxal Phosphate (PLP)
October 21
Glutamate Family of Amino Acids
Synthesis of Proline from Glutamate
Synthesis of Arginine from Glutamate via Ornithine 
October 23
Flux in Metabolism
Oxaloacetate Family of Amino Acids
Regulation of Branched Biosynthetic Pathways
October 25
Biosynthesis of Essential Amino Acids - due
Generation of Formyl and Methyl Groups-
Folate Metabolism
Urea Cycle
Amino Acid Catabolism
October 28
Creatine Creates Controversy p1-5
October 30
Sick Kids with an Unusual Organic Aciduria p1, p2, Summary
November 1
Human Starvation
Metabolic Limits of Human Performance
November 4
Midterm Exam Review session.
November 6
Midterm Exam
8:00 am - 10 am
November 8
Plant vs Animals in the Dining Hall.  Page 1
November 11
Plant vs Animals in the Dining Hall.  Page 2
November 13
Plant vs Animals in the Dining Hall
Page 3
November 15
Plant vs Animals in the Dining Hall. Page 4, Page 5, and Summary

November 18
Begin Final Group Project
November 20
Group Project
November 22
Group Project
November 25
Group Project
November 27
Thanksgiving Break
November 29
Thanksgiving Break
December 2
Group Project due
Group Project Presentations
December 4
Group Project Presentations
On-line course evaluations due
Final Exam 
7-10 PM Monday, 9 December,  in 206 Brown Lab

Return to Department's Home Page, CHEM-643 Home Page, CHEM-643 Syllabus, or Hal White's Home Page.
Last updated 18 January 2014 by Hal White. (halwhite at udel.edu)
Copyright 2013, Harold B. White, Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716