Mechanistic Analysis
Mechanistic
insight drives our ability to design new reactions, catalysts and
materials. Our group utilizes a number of tools (2-D and VT-NMR,
mass spectrometry, x-ray crystallography) to study the structure and
kinetics of reactions. We also use computational tools, through
collaboration with Robert Bach and Olga Dmintrenko, to gain insight
into reaction mechanism.
Some recent publications in this area
Tarwade,
V.; Dmitrenko, O.; Bach, R. D.; Fox, J. M. "The Curtius
Rearrangement of Cyclopropyl- and Cyclopropenoyl Azides. A Combined
Theoretical and Experimental Mechanistic Study" J. Org. Chem. accepted
Pallerla,
M. K.; Yap, G. P. A.; Fox, J. M. “Co-complexes Derived
from Alkene Insertion to Alkyne-dicobaltpentacarbonyl complexes:
Insight into the Regioselectivity of Pauson-Khand Reactions of
Cyclopropenes” J. Org. Chem. 2008, 73, 6137-6141
Dong,
Z.; Yap, G. P. A.; Fox, J. M. “trans-Cyclohexane-1,2-diamine
Is a Weak Director of Absolute Helicity in Chiral Nickel-Salen
Complexes” J. Am. Chem. Soc. 2007, 129, 11850-11853.
22) Liu,
X.; Fox, J. M. “Enantioselective, Facially Selective
Carbomagnesation of Cyclopropenes” J. Am. Chem. Soc. 2006, 128,
5600-5601.
21) Yang,
Z.; Xie, X.; Fox, J. M. “Diastereoselective Synthesis of
Methylenecyclopropanes from Chiral Cyclopropene Derivatives” Angew.
Chem. Int. Edit. 2006, 45, 3960-3962.
Fox, J. M.; Dmintrenko, O.; Liao, L.-a.; Bach. R.
D. “Computational Studies of Nucleophilic Substitution at Carbonyl
Carbon: Applications to Organic Synthesis” J. Org. Chem. 2004, 69,
7317-7328.
Liao,
L.-a.; Zhang. F.; Dmintrenko, O.; Bach, R.
D.; Fox, J. M. “A Reactivity/Affinity Switch for Parallel Kinetic
Resolution: α-Amino Acid
Quasienantiomers and the Resolution of
Cyclopropene Carboxylic Acids” J. Am. Chem. Soc. 2004, 126, 4490-4491.
