We're developing portable systems for rapid bedside analysis of target biomarkers.
- In one application we're looking to detect trace levels of proteins indicative of a heart attack or stroke. The goal was to develop a sensor that can be carried by first responders or deployed at any clinic to perform a protein panel assay in less than 10 min. using only a finger-prick of blood.
- In another application we're developing SPR sensors to detect small molecule biomarkers in urine and other bodily fluids.
SPR sensorgram with the fiber optic sensor for determining proteins in buffer(left) and serum(right).
Sensorgrams of imprinted and nonimprinted polymer layers to glucose spiked urine. The sensors are exposed to five cycles of (i)buffer wash, (ii)urine), (i)buffer wash, (iii)NaOH regeneration. Note that the imprinted polymer has the greater signal during exposure to urine from specifically and nonspecifically bound glucose and also during the second buffer wash from specifically bound glucose. At the bottom is the spr shift from a noncoated reference sensor.