Macromolecular Chime Demo
You can download a free copy of Chime from this web site: (http://www.mdlchime.com/chime/).

    1. Introduction to Chime 3D computer models 
      1. Buckminsterfullerene 
      2. The double helix of DNA
      3. Watson-Crick Base Pairs 
      4. An enzyme: Enoyl-CoA Hydratase
    2. Peptides
      1. The peptide bond
      2. A tripeptide
      3. A tetrapeptide
    3. Secondary Structure
      1. The alpha helix 
        1. The alpha helix at low resolution 
        2. The alpha helix at high resolution 
        3. A mystery alpha helix
      2. Beta sheets and turns 
        1. The beta strand 
        2. Antiparallel beta sheets 
        3. Beta turns 
        4. Parallel beta sheets
    4. Disulfide Bonds
      1. Nerve growth factor 
      2. Insulin
    5. Protein Folds
      1. Folds in the all-beta class 
        1. Beta sandwiches 
        2. Beta barrels 
        3. Beta helices
      2. Folds in the all-alpha class 
        1. Assemblies of three to six helices 
        2. Assemblies of long helices 
        3. Large assemblies
      3. Folds in the alpha + beta class 
        1. Helices on one side of a beta sheet 
        2. Helices on both sides of the beta sheet

        3.  
    6. Quaternary Structure
      1. Human immunoglobulin G 
    7. Supercoiled Protein Motifs
      1. The collagen triple helix

      2. Protein Cooperativity and Allosterism
    1. Glycogen Phosphoryase  - R-state vs. T-state
    2. Oxygen Transport 
      1. Myoglobin
        1. The globin fold 
        2. The oxygen-binding pocket 
        3. Glycine/glycine helix crossing 
        4. Oxygen binding alters 3° structure
      2. Hemoglobin-- An allosteric protein
        1. Quaternary structure 
        2. Ion pairs in deoxyhemoglobin 
        3. BPG binding site in deoxyHb 
        4. Sickle cell hemoglobin
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