The Schneider Lab

 

Design, Synthesis, and Efficacy of Novel Amino Acids, Peptides, and Proteins

Our research entails the de novo design of functional peptides and proteins. Ongoing efforts are highly interdisciplinary and span historically disparate disciplines of science such as materials science, inorganic and organic chemistries, chemical synthesis and biophysics. As chemists, we are not limited to the naturally occurring amino acids in our designs and we often incorporate non-natural residues, which we design and synthesize, into peptides and proteins to impart unique structural and functional properties. General design strategies for the preparation of peptide-based antibiotics, recognition motifs for protein folding specificity, peptide and organoarsenical-based probes, as well as bio-inspired materials are actively being pursued in the Schneider Lab.

Keywords: De Novo Design, Self-Assembly, Peptide Materials, Antibiotics, Organoarsenical