Dr. Vladimir N. Simirskii

Postdoctoral Fellow
Laboratory of Melinda K. Duncan

Contact

Simirskii

Office: 311 Wolf Hall
Lab: 266 Wolf Hall

Mailing address:
Department of Biological Sciences
Wolf Hall
University of Delaware
Newark, DE 19716

Phone: (302) 831-6503
Fax: (302) 831-2281
E-mail: simir@udel.edu

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Education

B.S.: Moscow State University, Russia
Ph.D., Postdoctoral: Russian Academy of Sciences, Russia

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Research Interests

The lens is a true epithelium with the basal surface of every transcriptionally active cell attached to a modified basement membrane, the lens capsule. While numerous studies have suggested that extracellular matrix molecules can influence lens cell biology, little is known about either the molecular composition of the capsule or the nature of the receptors present on lens cells that mediate lens cell/lens capsule interactions. We have previously shown that collagen IV is present in the lens capsule and that the molecular composition of the collagen IV network changes during lens development. We are now investigating the functional significance of these changes both in vivo and in vitro as well as the molecular mechanisms by which lens cells could detect a changing collagen IV network.

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Selected Publications

Collinge J.E., Simirskii V.N., and Duncan M.K. (2005) Expression of tissue plasminogen activator during eye development. Exp. Eye Res., v. 81, p. 90-96.

Simirskii V.N., Panova I.G., Sologub A.A., and Aleinikova K.S. (2003) Localization of crystallins in Muller cells in the grass frog retina. Ontogenesis v. 34, p. 365-370.

Simirskii V.N. and Aleinikova K.S. (2002) The 23-kDa polypeptide from common frog lens: isolation, characterization and cellular localization. Ontogenesis v. 33, p. 276-284.

Simirskii V.N., Aleinikova K.S., and Mikhailov A.T. (1999) Amphibian
epidermal polypeptide patterns: Identification and developmental dynamics. Int. Symp. "The Front. Biol. Amphibia", Japan. p. 58.

Simirskii V.N., Aleinikova K.S., and Mikhailov A.T. (1999) Specific proteins of lens epithelium of the frog eye. Dokl. Acad. Sci., v. 365, p. 704-706.

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