Dr. William Cain

Assistant Professor

Contact

Cain

Office: 215 McKinly Lab

Mailing address:
Department of Biological Sciences
Wolf Hall
University of Delaware
Newark, DE 19716

Phone: (302) 831-8098
Fax: (302) 831-2281
E-mail: will@udel.edu

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Education

B.S., Ph.D.: University of Delaware

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Research Interests

I currently conduct research in close association with Dr. David Usher at the University of Delaware and Dr. Daniel Rader at the University of Pennsylvania. This research focuses on lipoprotein function in humans and other vertebrates. I have two main research interests:

• Metabolism of Lipoprotein(a). High plasma levels of lipoprotein(a) are considered a risk factor for coronary heart disease and yet we presently know very little about the mechanisms involved in it’s plasma clearance. We are presently examining the mechanisms involved in the plasma clearance of Lp(a) in genetically modified mice.
• Evolution of Lipoproteins. We are examining lipoprotein metabolism in turtles with specific interest in the identification of apolipoproteins with homology to human apolipoproteins.

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Teaching

• BISC 208 - Introductory Biology II
• BISC 413 - Advanced Genetics Laboratory
• BISC 601 - Immunochemistry
• BISC 604 - Nucleic Acids Laboratory

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Selected Publications

Chen, X., T.P. Patel, W.J. Cain, and M.K. Duncan. 2006. Production of monoclonal antibodies against prox1. Hybridoma (Larchmt) 25:27-33.

Cain, W.J., J.S. Millar, A.S. Himebauch, U.J.F. Tietge, C. Maugeais, D. Usher, and D.J. Rader. 2005. Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a]. J. Lipid Res. 46:2681-2691.

Ikewaki, K., W. Cain, F. Thomas, R. Shamburek, L.A. Zech, D. Usher, H.B. Brewer Jr., and D.J. Rader. 2004. Abnormal in vivo metabolism of apoB-containing lipoproteins in human apoE deficiency. J. Lipid Res. 45:1302-1311.

Maugeais, C., U.J. Tietge, U.C. Broedl, D. Marchadier, W. Cain, M.G. McCoy, S. Lund-Katz, J.M. Glick, and D.J. Rader. 2003. Dose-dependent acceleration of high-density lipoprotein catabolism by endothelial lipase. Circulation. 108(17):2121-6.

Cain, W., L. Song, G. Stephens, and D. Usher. Characterization of lipoproteins from the turtle, Trachemys scripta elegans, in fasted and fed states. 2003. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 134(4):783-94.

Tietge, U.J., C. Maugeais, W. Cain, and D.J. Rader. 2003. Acute inflammation increases selective uptake of HDL cholesteryl esters into adrenals of mice overexpressing human sPLA2. Am. J. Physiol. Endocrinol. Metab. 285(2):403-11.

Vaisman, B.L., G. Lambert, M. Amar, C. Joyce, T. Ito, R.D. Shamburek, W.J. Cain, J. Fruchart-Najib, E.D. Neufeld, A.T. Remaley, H.B. Brewer Jr., and S. Santamarina-Fojo. 2001. ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. J. Clin. Invest. 108(2):303-309.

DiAngelo J., T. Vasavada, W. Cain and M. Duncan. 2001. Production of monoclonal antibodies against chicken Pop1 (BVES). Hybrid Hybridomics. 20(5-6):377-382.

Tietge U., C. Maugeais, W. Cain, D. Grass, J. Glick, F.C. de-Beer and D. Rader. 2000. Overexpression of secretory phospholipase A(2) causes rapid catabolism and altered tissue uptake of high density lipoprotein cholesteryl ester and apolipoprotein A-I. J-Biol-Chem. 275(14):10077-10084.

Auerbach B., W. Cain, M. Ansong, R. Newton, U. Saxena and C. Bisgaier. 1999. Lipoprotein lipase greatly enhances the retention of lipoprotein(a) to endothelial cell-matrix. Atherosclerosis. 142(1):89-96.

Bdeir K., W. Cain, G. Canziani, I. Chaiken, J. Weisel, M. Koschinsky, R. Lawn, P. Bannerman, B. Sachais, A. Kuo, M. Hancock, J. Tomaszewski, P. Raghunath, T. Ganz, A. Higazi and D. Cines. 1999. Defensin promotes the binding of lipoprotein(a) to vascular matrix. Blood. 94(6):2007-2019.

Higazi A., E. Lavi, K. Bdeir, A. Ulrich, D. Jamieson, D. Rader, D. Usher, W. Cain, T. Ganz, D. Cines. 1997. Defensin stimulates the binding of Lp(a) to human vascular endothelial and smooth muscle cells. Blood. 89(12):4290-4298.

Wassmer G., W. Cain, and T. Page. 1996. Photoperiodic regulation of hemolymph protein in the woodroach Parcoblatta pennsylvanica. J. Insect Physiol. 42:851-858.

Rader, D.J., W. Mann, W. Cain, H. Kraft, D. Usher. L. Zech, J. Hoeg, J.Davignon, P. Lupien, M. Grossman, J. Wilson and H. Brewer. 1995. The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans. J. Clin. Inves. 95(3):1403-1408.

Rader, D.J., W. Cain, G. Talley, L. Zech, D. Usher and H. Brewer. 1994. The inverse association of plasma lipoprotein(a) concentration with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism is not differences in Lp(a) catabolism but to differences in production rates. J. Clin. Inves. 93(6):2758-2763.

Rader, D.J., W. Cain. L. Zech, D. Usher and H. Brewer. 1993. Variation in lipoprotein(a) concentrations among individuals with the same apolipoprotein(a) isoform is determines by the rate of lipoprotein(a) production. J. Clin. Inves. 91(2):443-447.

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