Nicholas J. Petrelli, M.D., FACS

Adjunct Professor
Bank of America Endowed Medical Director, Helen F. Graham Cancer Center
Professor of Surgery, Thomas Jefferson University

Contact

Petrelli

Helen F. Graham Cancer Center
4701 Ogletown Stanton Road
Suite 1233
Newark, DE 19713

Phone: (302) 623-4550
Fax: (302) 623-4554
E-mail: npetrelli@christianacare.org

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Education

A.B.: University of Notre Dame
M.D.: Tulane Medical School

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Research Interests

My research interests are in the early detection and primary and secondary prevention of colorectal cancer. This is inclusive of establishing a program where individuals from high risk cancer families can undergo genetic counseling for potential genetic testing and subsequently undergo increase surveillance, prophylactic surgery or chemopreventive therapy. I also collaborate with researchers at the University of Delaware on projects related to development of biomarkers for studying cancer progression and metastasis, and for development of new chemotherapeutic agents targeting metastatic cancers.

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Current Projects

• AstraZeneca, Early Detection of Lung Cancer
• NIH, Heparan Sulfate Proteoglycans in Bone Stromal Metastases (with Mary C. Farach-Carson)
• NIH/NCI, Chair, NSABP Colorectal Committee
• NCI, NCI Community Cancer Centers Program

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Selected Publications

O'Dwyer PJ, Eckhardt SG, Haller DG, Tepper J, Ahmed D, Hamilton S, Rothenberg M, Petrelli N, Lenz HJ, Diasio R, DuBois R, Sargent D, Sloan J, Johnson D, Comis RL, O'Connell MJ. Priorities in colorectal cancer research: recommendations from the GI Scientific Leadership Council of the Coalition of Cancer Cooperative Groups. J Clin Oncol, 25(16): 2313-2321, 2007.

Kuebler P, Wieand HS, O'Connell MJ, Smith RE, Colangelo L, Yothers G, Petrelli N, Findlay M, Sealy T, Atkins J, Wolmark N. Oxaliplatin combined with weekly bolus 5-fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer. Results from NSABP C-07. J Clin Oncol, 25(16): 2198-2203, 2007.

Smith J, Mahmood S, Song F, Morrow A, Smiraglia D, Zhang Y, Rajput A, Higgins M, Krumm A, Petrelli N, Costello J, Green A, Nagase H, Plass C, Held W. Identification of genomic regions of DNA methylation in 3o genomic regions that are associated with upregulation of gene expression in colorectal cancer. Epigenetics, 2(3): 161-172, 2007.

Khatri V, Chee K, Petrelli N. Modern multimodality approach to hepatic colorectal metastases. Solutions and Controversies Surgical Oncology, 16(1): 71, 2007.

Brenner B, Stoler D, Rodriguez L, Karpenko M, Swede H, Petrelli N, Anderson G. Allelic losses at genomic instability-associated loci in villous adenomas and adjacent colorectal cancers. Cancer Genetics and Cytogenetics, 174(1): 9-15, 2007.

Esquivel J, Sticca R, Sugarbaker P, ... Petrelli N, ... Sebbag G. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Annals of Surgical Oncology, 14(1): 128-133, 2007.

Metreveli R, Sahm K, Abdel-Misih R, Petrelli N. Major pancreatic resections for suspected cancer in a community based teaching hospital: lessons learned. J Surg Onc, 95: 201-206, 2007.

Bartos, J, Gaile, D, McQuaid, D, Conroy, J, Darbary H, Nowak, N, Block, A, Petrelli, N, Mittleman A, Stoler, D, Anderson, G. A CGH local copy number aberrations associated with overall copy number genomic instability in colorectal cancer: coordinate, involvement of the regions including BCR and ABL. Mutation Research, 615(1-2): 1-11, 2007.

Perkins, S, Sahm, K, Marando, G, Dickson-Witmer, D, Pahnke, G, Petrelli, N, Berkowitz, I, Soteropoulous, P, Aris, V, Dunn, S, Kruger, L. Analysis of EBV reservoirs in paired blood and breast cancer primary biopsy specimens by real time PCR. Breast Cancer Research, 8(6): R70, 2006.

Khatri V, Shah M, Petrelli N, Gibbs J, Rodriguez Bigas M. Type-2 dominant cytokine gene expression following hepatic surgery. Journal of Hepato-Biliary Pancreatic Surgery, 13(5): 442-9, 2006.

Swede H, Bartos JD, Chen N, ... Petrelli NJ, et al. Genomic profiles of colorectal cancers differ based on patient smoking status. Cancer Genet Cytogenet, 168(2): 98-104, 2006.

Bartlett D, Berlin J, Lauwers G, Messersmith W, Petrelli N, Venook A. Chemotherapy and regional therapy of hepatic colorectal metastases: expert consensus statement. Annals of Surgical Oncology 13(10): 1284-1294, 2006.

Frelick R, Strusowski T, Grusenmeyer P, Petrelli N. Oncology nurse care coordinators as navigators improving cancer disease management and the patient experience. Oncology Issues, 21(4): 26-30, 2006.

Datta R, Petrelli N, Ramzy J. Evaluation and management of incidentally discovered thyroid nodules. Surgical Oncology 15: 33-42, 2006.

Petrelli N. Surgical management of liver metastases from colorectal cancer. Clinical Advances in Hematology and Oncology 4(9): 673-75, 2006.

Grusenmeyer P, Petrelli N, Strusowski P. Developing and operating multidisciplinary disease specific clinics. Community Oncology 3(6): 26, 2006.

Lembersky B, Wieand S, Petrelli N, O'Connell M, Smith R, Wolmark N. Oral uracil-tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: Results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06. J Clin Oncol 24(13): 2059-2064, 2006.

Petrelli N. Expressing the prochemotherapy position on treatment of synchronous colorectal metastases in the asymptomatic patient. Annals of Surgical Oncology. 13(2): 137-140, 2006.

Petrelli N, Abruzzese J, Mansfield P, Minsky B. Hepatic Resection: The Last Surgical Frontier for Colorectal Cancer. J. Clin Oncol, 23(20): 4475, 2005.

Rousseau D, Thomas C, Petrelli N, Kahlenberg M. Squamous cell carcinoma of the anal canal. Surg Oncol. 14(3): 121-132, 2005.

Khatri V, Petrelli N, Belghiti J. Extending the frontiers of surgical therapy for hepatic colorectal metastases: Is there a limit? J. Clin Oncol, 23(33): 8490-8499, 2005.

Desch CE, Benson AB, Somerfeld M, Flynn PJ, Krause C, Loprinzi CL, Minsky B, Pfister DG, Virgo KS, Petrelli NJ. Colorectal cancer surveillance: 2005 update of American Society of Clinical Oncology practice guideline. J Clin Oncol, 23(33): 8512-8519, 2005.

Metreveli R, Sahm K, Denstman F, Abdel-Misih R, Petrelli N. Hepatic resection at a major community-based teaching hospital can result in good outcome. Annals of Surgical Oncology, 12(2): 133-137, 2005.

Pandya KJ, Lefkopoulou M, Petrelli NJ, Vaughn DJ, Smith TJ, Harris JE, Haller DG. Phase II study of cisplatin and 5-fluorouracil (PF) and mitomycin c, vincristine, cisplatin and 5-fluorouracil (MVPF) in patients with metastatic large bowel cancer: An ECOG Study (E1285). Oncology. 66(2): 118-25, 2004.

Bartos J, Stoler D, Matsui S, Swede H, Willmott L, Sait S, Petrelli N, Anderson G. Genomic heterogeneity and instability in colorectal cancer: spectral karyotyping, glutathione transferase-M1 and ras. Mutat Res, 568(2): 283-292, 2004.

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