Dr. Mary C. Farach-Carson

Professor
Secondary Faculty, Department of Materials Science and Engineering
Affiliated Faculty, Delaware Biotechnology Institute
Director, Center for Translational Cancer Research

Contact

Farach-Carson

Office: 326 Wolf Hall

Mailing address:
Dept. of Biological Sciences
326 Wolf Hall
University of Delaware
Newark, DE 19716

Phone: (302) 831-2277
Fax: (302) 831-2281
E-mail: farachca@udel.edu

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Education

B.S.: University of South Carolina
Ph.D.: Medical College of Virginia
Postdoctoral: University of Texas, M.D. Anderson Cancer Center

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Research Interests

Research in Dr. Farach-Carson's laboratory relates to the role of extracellular matrix in the progression of cancer following metastasis from primary sites, such as prostate or breast, to bone. In many cases, primary tumors are fairly slow growing and do not become life-threatening until they form tumors in bone. The growth factors sequestered in bone matrix provide a very rich environment to promote the growth of cancer cells that invade there. Many of these growth factors are bound to a class of proteoglycans that contain heparan sulfate which regulate their bioactivity. Studies in the laboratory are aimed at identifying and isolating the growth factors responsible for cancer growth and progression with the long term aim of developing "molecular drugs" to combat cancer metastasis. Three dimensional models are used to study the behavior of cancer cells and to test their susceptibility to anti-cancer drugs that reduce cancer growth and progression. Industrial partnerships support the development of novel cancer diagnostics based on the principle that cancer biomarkers are created by cancer growth in bone.

A multidisciplinary project involves the use of proteoglycans, particularly those bearing heparan sulfate chains such as perlecan, in engineering of connective tissues such as bone, cartilage or salivary gland. Cell and molecular engineering strategies are being developed that facilitate controlled tissue growth and differentiation. Growth factor binding and delivery by engineered proteoglycans is being used in oral surgery and orthopaedic applications. Several engineering partnerships both within and outside the university exist to support these studies.

A trainee doing research in this laboratory would be exposed to a variety of techniques including cell culture, recombinant and natural protein purification and analysis, calcium imaging, cloning and molecular biology, microRNAs, immunodetection and immunohistochemistry, and various pre-clinical cancer models.

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Current Projects

NIH, Biochemistry of Uterine Heparan Sulfate Receptors (with Dan Carson).
NIH, Characterization of a Putative Plasma Membrane Vitamin D Receptor (with Susan Safford, Lincoln University).
NIH, Heparan Sulfate Proteoglycans in Bone Stromal Metastasis (with Leland Chung, Emory University).
NIH, Perlecan and Heparanase in Cartilage Growth and Healing (with Catherine Kirn-Safran)
NIH, Electrospun Scaffolds for Testing Anti-Neoplastics (with Chu Zhang, Robert Sikes, John Rabolt)

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Teaching

BISC 413 - Advanced Genetics Laboratory
BISC 612* - Advanced Cell Biology
BISC 665 - Advanced Molecular Biology and Genetics
BISC 806* - Topics in Extracellular Matrix
BISC 833* - Translational Biology
Pre-dental advisor
EDucate for a Cure faculty sponsor
Working in the High Risk Family Cancer Registry (with Helen F. Graham Cancer Center), e-mail for details.

*Course web site available through MyCourses

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Research Group

Chu Zhang, Ph.D. - Research Associate III (Ph.D., University of Delaware). Studying the biological function of perlecan in apoptosis of prostate cancer cells and biological interactions between osteoblasts and prostate cancer cells at sites of bony metastases; using microarray analysis to characterize phenotypic changes in prostate cancer cells at sites of bony metastasis. (Research Coordinator, CTCR)
Benjamin Rohe, M.S. - Research Associate II (M.S., University of Delaware). Molecular biology and ribozyme production; cell culture, general lab maintenance.
Anissa Brown, B.A. - Graduate Student (B.A., University of Delaware). Studying the role of heparanase in chondrogenesis with particular interest in the application to tissue engineering of cartilage. Role of heparanase in the delivery of heparin binding growth factors in the developing mouse limb.
Rob Long, B.S. - Research Associate III (B.S., University of Delaware). In vitro studies of cell growth and differentiation, protein profiling using mass spectroscopy and HPLC techniques. (Core Coordinator, CTCR)
Rose O'Connor, B.S. - Graduate Student (B.S., Lehigh University). Studying the dysregulation of gene silencing in Rett Syndrome and effects of MeCP2 mutations on osteoblast function and bone resorption. (Co-sponsored by Carolyn Schanen, A.I. duPont Hospital for Children)
Lynn Opdenaker, B.S. - Graduate Student (B.S., Ursinus College). Studying the role of heparin interacting protein (HIP) in prostate cancer disease anc progression including prostate cancer cell interactions with surrounding bone marrow stroma.
Angela Petiak, B.S. - Graduate Student (B.S., Lebanon Valley College). Studying the role of perlecan as an extracellular scaffold modulating signaling pathways in prostate cancer cells.
William Thompson, B.S. - Graduate Student (B.S., Lee University). Studying the role of perlecan and other candidate extracellular matrix molecules in the transmission of mechanical stimuli among osteocytes in bone.
David Tuke, B.A. - Research Specialist (B.A., University of Delaware). Using a mouse model of osteoarthritis to study healing of the knee and the role of heparan sulfate proteoglycans in cartilage regeneration.
Undergraduate Researchers: Kyle Green, Becky Grey, Brian Grindel, Monica Holland, Neeta Jain, Allison Kasmari, Susan Lee, Amber Majid, Matt Richards, Katherine Townsend.

Carsons lab group

The Laboratory for Endocrine and Extracellular Matrix Biology

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Selected Publications

Brown, A.J., Alicknavitch, M., D'Souza, S.S., Daikoku, T., Kirn-Safran, C., Marchetti, D., Carson, D.D., and Farach-Carson, M.C. Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. Bone, (resubmitted).

Cooper, C.R., Graves, B., Pruitt, F., Chaib, H., Lynch, J.E., Cox, A.K., Sequeria, L., van Golen, K.L, Evans, A., Czymmek, K., Bullard, R.S., Donald, C.D., Sol-Church, K., Gendernalik, J.D., Weksler, B., Farach-Carson, M.C., Macoska J.A., Sikes, R.A. and Pienta, K.J. Novel surface expression of Reticulocalbin 1 on bone endothelial cells and human prostate cancer cells is regulated by TNF-a. J. Cell. Biochem., (resubmitted).

D'Souza, S.S., Fazleabas, A.T., Banerjee, P., Sherwin, J.R., Sharkey, A.M., Farach-Carson, M.C., and Carson, D.D. Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells. Biol. Reprod., 78(2):316-323, 2008.

Farach-Carson, M.C. and Carson, D.D. Perlecan: A multifunctional extracellular proteoglycan scaffold in embryo implantation and placentation. Glycobiology, 17(9):897-905, 2007.

Farach-Carson, M.C., Brown, A.J., Lynam, M., Safran, J.B., and Carson, D.D. A novel peptide sequence in perlecan domain IV supports cell adhesion and spreading. Matrix Biology, 27(2):150-160, 2007.

Yeo, H., Beck, L.H., Thompson, S.R., Farach-Carson, M.C., McDonald, J.M., Clemens, T.L. and Zayzafoon, M. Conditional disruption of calcineurin B1 in osteoblasts increases bone formation and reduces bone resorption. J. Biol. Chem., 282(48):35318-35327, 2007.

D'Souza, S.S., Daikoku, T., Farach-Carson, M.C., and Carson D.D. Heparanase expression and function during early pregnancy in mice. Biol. Reprod., 77(3):433-441, 2007.

O'Connor, J.C., Farach-Carson, M.C., Schneider, C.J., and Carson, D.D. Co-culture of bone marrow stromal cells with prostate cancer cells alters endoglin expression and attenuates TGF-β signaling in reactive bone stroma. Mol. Cancer Res., 5(6):585-603, 2007.

Casper, C.L., Yang, W., Farach-Carson, M.C., and Rabolt, J.F. Coating electrospun collagen and gelatin fibers with perlecan domain I for increased growth factor binding. Biomacromolecules, 8(4):1116-1123, 2007.

Chen, Q., Sivakumar, P., Barley, C., Peters, D.M., Gomes, R.R., Farach-Carson, M.C., and Dallas, S.L. Potential role for heparan sulfate proteoglycans in regulation of TGF-b by modulating assembly of latent TGF-β binding protein-1 (LTBP1). J. Biol. Chem., 282(36):26418-26430, 2007.

Rohe, B., Safford, S., Nemere, I., and Farach-Carson, M.C. Regulation of expression of 1,25D₃-MARRS/ERp57/PDIA3 in rat IEC-6 cells by TGFβ and 1,25(OH)₂D₃. Steroids, 7(2):144-150, 2007.

Huang, W.C., Wu, D., Xie, Z., Zhau, H.E., Nomura, T., Zayzafoon, M., Pohl, J., Hsieh, C.L., Weitzmann, M.N., Farach-Carson, M.C., and Chung, L.W. β2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis. Cancer Res., 66(18):9108-9116, 2006.

Muir, C. , Chung, L.W.K., Carson, D.D., and Farach-Carson, M.C. Hypoxia increases VEGF-A production by prostate cancer and bone marrow stromal cells and initiates paracrine activation of bone marrow endothelial cells. Clin. Exp. Metastasis, 23(1):75-86, 2006.

Nemere, I., Wilson, C., Hendricks, D., Jensen,, W., Steinbeck, M., Rohe, B. and Farach-Carson, M.C. Mechanism of 24,25-dihydroxyvitamin D₃-mediated inhibition of rapid, 1,25-dihydroxyvitamin D₃-induced responses: Role of reactive oxygen species. J. Cell Biochem., 99:1572-1581, 2006.

Datta, M.W., Hernandez A.M., Schlich M.J., Kahler A.J., Degueme A.M., Dhir R., Shah R.B., Farach-Carson M.C., Barrett A., and Datta, S. Perlecan, a candidate gene for the CABP locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway. Molecular Cancer, 5:9, 2006.

Gomes, R.R. Jr., Van Kuppevelt, T.H., Farach-Carson, M.C., and Carson, D.D. Spatiotemporal distribution of heparan sulfate epitopes during murine cartilage growth plate development. Histochem. Cell Biology, 126:713-722, 2006.

Bergh, J.J., Shao, Y., Puente, E. Duncan, R.L. and Farach-Carson, M.C. Osteoblast Ca²⁺ Permeability and voltage-sensitive Ca²⁺ calcium channel (VSCC) expression is temporally regulated by 1,25-dihydroxyvitamin D₃. Am. J. Physiol. (Cell Physiol.), 290(3):C822-831, 2006.

Gomes, R.R. Jr., Joshi, S.S., Farach-Carson, M.C., and Carson, D.D. Ribozyme-mediated perlecan knockdown impairs chondrogenic differentiation of C3H10T1/2 fibroblasts. Differentiation, 74(1):53-63, 2006.

Yang, W.D., Gomes, R.R. Brown, A.J., Burdett, A.R. Alicknavitch, M., Farach-Carson, M.C., and Carson, D.D. Chondrogenic differentiation on perlecan domain I, collagen II, and bone morphogenetic protein 2-based matrices. Tissue Engineering, 12(7):2009-2024, 2006.

Savore, C., Liu, Riting, Muir, C., Shu, J., Zhau, H.E., Chung, L.W.K., Carson, D.D., and Farach-Carson, M.C. Perlecan knockdown in prostate cancer cells reduces heparin binding growth factor responses in vitro and tumor growth in vivo. Clin. Exp. Metastasis, 22:377-390, 2005.

Yang, W.D., Gomes, R.R., Alicknavitch, M., Farach-Carson, M.C., and Carson, D.D. Perlecan domain I promotes FGF-2 delivery in collagen I fibril scaffolds. Tissue Engineering, 11:76-89, 2005.

Al-Shami, R., Sorensen, E.S., Ek-Rylander, B., Andersson, G., Carson, D.D, and Farach-Carson, M.C. Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway. J. Cell Biochem., 94:1218-33, 2005.

Shin, H., Temenoff, J.S., Bowden, G.C., Zygourakis, K., Farach-Carson, M.C., Yaszemski, M.J., and Mikos, A.G. Osteogenic differentiation of rat bone marrow stromal cells cultured on Arg-Gly-Asp modified hydrogels without dexamethasone and β-glycerol phosphate. Biomaterials, 17:3645-54, 2005.

Hecht, J.T., Hayes, E., Haynes, R., Cole, W.G., Long, R.J., Farach-Carson, M.C., and Carson D.D. Differentiation-induced loss of heparan sulfate in human exostosis derived chondrocytes. Differentiation, 73:212-21, 2005.

Rohe, B., Safford, S.E., Nemere, I. and Farach-Carson, M.C. Identification and characterization of 1,25D₃-membrane-associated rapid response, steroid (1,25D₃-MARRS)-binding protein in rat IEC-6 cells. Steroids, 70:458-63, 2005.

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Dr. Mary C. Farach-Carson Professor Secondary Faculty, Department of Materials Science and Engineering Affiliated Faculty, Delaware Biotechnology Institute Director, Center for Translational Cancer Research Contact Farach-Carson Office: 326 Wolf Hall Mailing address: Dept. of Biological Sciences 326 Wolf Hall University of Delaware Newark, DE 19716 Phone: (302) 831-2277 Fax: (302) 831-2281 E-mail: farachca@udel.edu Go to top of page Education B.S.: University of South Carolina Ph.D.: Medical College of Virginia Postdoctoral: University of Texas, M.D. Anderson Cancer Center Go to top of page Research Interests Research in Dr. Farach-Carson's laboratory relates to the role of extracellular matrix in the progression of cancer following metastasis from primary sites, such as prostate or breast, to bone. In many cases, primary tumors are fairly slow growing and do not become life-threatening until they form tumors in bone. The growth factors sequestered in bone matrix provide a very rich environment to promote the growth of cancer cells that invade there. Many of these growth factors are bound to a class of proteoglycans that contain heparan sulfate which regulate their bioactivity. Studies in the laboratory are aimed at identifying and isolating the growth factors responsible for cancer growth and progression with the long term aim of developing "molecular drugs" to combat cancer metastasis. Three dimensional models are used to study the behavior of cancer cells and to test their susceptibility to anti-cancer drugs that reduce cancer growth and progression. Industrial partnerships support the development of novel cancer diagnostics based on the principle that cancer biomarkers are created by cancer growth in bone. A multidisciplinary project involves the use of proteoglycans, particularly those bearing heparan sulfate chains such as perlecan, in engineering of connective tissues such as bone, cartilage or salivary gland. Cell and molecular engineering strategies are being developed that facilitate controlled tissue growth and differentiation. Growth factor binding and delivery by engineered proteoglycans is being used in oral surgery and orthopaedic applications. Several engineering partnerships both within and outside the university exist to support these studies. A trainee doing research in this laboratory would be exposed to a variety of techniques including cell culture, recombinant and natural protein purification and analysis, calcium imaging, cloning and molecular biology, microRNAs, immunodetection and immunohistochemistry, and various pre-clinical cancer models. Go to top of page Current Projects NIH, Biochemistry of Uterine Heparan Sulfate Receptors (with Dan Carson). NIH, Characterization of a Putative Plasma Membrane Vitamin D Receptor (with Susan Safford, Lincoln University). NIH, Heparan Sulfate Proteoglycans in Bone Stromal Metastasis (with Leland Chung, Emory University). NIH, Perlecan and Heparanase in Cartilage Growth and Healing (with Catherine Kirn-Safran) NIH, Electrospun Scaffolds for Testing Anti-Neoplastics (with Chu Zhang, Robert Sikes, John Rabolt) Go to top of page Teaching BISC 413 - Advanced Genetics Laboratory BISC 612* - Advanced Cell Biology BISC 665 - Advanced Molecular Biology and Genetics BISC 806* - Topics in Extracellular Matrix BISC 833* - Translational Biology Pre-dental advisor EDucate for a Cure faculty sponsor Working in the High Risk Family Cancer Registry (with Helen F. Graham Cancer Center), e-mail for details. Course web site available through MyCourses Go to top of page Research Group Chu Zhang, Ph.D.* - Research Associate III (Ph.D., University of Delaware). Studying the biological function of perlecan in apoptosis of prostate cancer cells and biological interactions between osteoblasts and prostate cancer cells at sites of bony metastases; using microarray analysis to characterize phenotypic changes in prostate cancer cells at sites of bony metastasis. (Research Coordinator, CTCR) Benjamin Rohe, M.S. - Research Associate II (M.S., University of Delaware). Molecular biology and ribozyme production; cell culture, general lab maintenance. Anissa Brown, B.A. - Graduate Student (B.A., University of Delaware). Studying the role of heparanase in chondrogenesis with particular interest in the application to tissue engineering of cartilage. Role of heparanase in the delivery of heparin binding growth factors in the developing mouse limb. Rob Long, B.S. - Research Associate III (B.S., University of Delaware). In vitro studies of cell growth and differentiation, protein profiling using mass spectroscopy and HPLC techniques. (Core Coordinator, CTCR) Rose O'Connor, B.S. - Graduate Student (B.S., Lehigh University). Studying the dysregulation of gene silencing in Rett Syndrome and effects of MeCP2 mutations on osteoblast function and bone resorption. (Co-sponsored by Carolyn Schanen, A.I. duPont Hospital for Children) Lynn Opdenaker, B.S. - Graduate Student (B.S., Ursinus College). Studying the role of heparin interacting protein (HIP) in prostate cancer disease anc progression including prostate cancer cell interactions with surrounding bone marrow stroma. Angela Petiak, B.S. - Graduate Student (B.S., Lebanon Valley College). Studying the role of perlecan as an extracellular scaffold modulating signaling pathways in prostate cancer cells. William Thompson, B.S. - Graduate Student (B.S., Lee University). Studying the role of perlecan and other candidate extracellular matrix molecules in the transmission of mechanical stimuli among osteocytes in bone. David Tuke, B.A. - Research Specialist (B.A., University of Delaware). Using a mouse model of osteoarthritis to study healing of the knee and the role of heparan sulfate proteoglycans in cartilage regeneration. Undergraduate Researchers: Kyle Green, Becky Grey, Brian Grindel, Monica Holland, Neeta Jain, Allison Kasmari, Susan Lee, Amber Majid, Matt Richards, Katherine Townsend. The Laboratory for Endocrine and Extracellular Matrix Biology Go to top of page Selected Publications Brown, A.J., Alicknavitch, M., D'Souza, S.S., Daikoku, T., Kirn-Safran, C., Marchetti, D., Carson, D.D., and Farach-Carson, M.C. Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. Bone, (resubmitted). Cooper, C.R., Graves, B., Pruitt, F., Chaib, H., Lynch, J.E., Cox, A.K., Sequeria, L., van Golen, K.L, Evans, A., Czymmek, K., Bullard, R.S., Donald, C.D., Sol-Church, K., Gendernalik, J.D., Weksler, B., Farach-Carson, M.C., Macoska J.A., Sikes, R.A. and Pienta, K.J. Novel surface expression of Reticulocalbin 1 on bone endothelial cells and human prostate cancer cells is regulated by TNF-a. J. Cell. Biochem., (resubmitted). D'Souza, S.S., Fazleabas, A.T., Banerjee, P., Sherwin, J.R., Sharkey, A.M., Farach-Carson, M.C., and Carson, D.D. Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells. Biol. Reprod., 78(2):316-323, 2008. Farach-Carson, M.C. and Carson, D.D. Perlecan: A multifunctional extracellular proteoglycan scaffold in embryo implantation and placentation. Glycobiology, 17(9):897-905, 2007. Farach-Carson, M.C., Brown, A.J., Lynam, M., Safran, J.B., and Carson, D.D. A novel peptide sequence in perlecan domain IV supports cell adhesion and spreading. Matrix Biology, 27(2):150-160, 2007. Yeo, H., Beck, L.H., Thompson, S.R., Farach-Carson, M.C., McDonald, J.M., Clemens, T.L. and Zayzafoon, M. Conditional disruption of calcineurin B1 in osteoblasts increases bone formation and reduces bone resorption. J. Biol. Chem., 282(48):35318-35327, 2007. D'Souza, S.S., Daikoku, T., Farach-Carson, M.C., and Carson D.D. Heparanase expression and function during early pregnancy in mice. Biol. Reprod., 77(3):433-441, 2007. O'Connor, J.C., Farach-Carson, M.C., Schneider, C.J., and Carson, D.D. Co-culture of bone marrow stromal cells with prostate cancer cells alters endoglin expression and attenuates TGF-β signaling in reactive bone stroma. Mol. Cancer Res., 5(6):585-603, 2007. Casper, C.L., Yang, W., Farach-Carson, M.C., and Rabolt, J.F. Coating electrospun collagen and gelatin fibers with perlecan domain I for increased growth factor binding. Biomacromolecules, 8(4):1116-1123, 2007. Chen, Q., Sivakumar, P., Barley, C., Peters, D.M., Gomes, R.R., Farach-Carson, M.C., and Dallas, S.L. Potential role for heparan sulfate proteoglycans in regulation of TGF-b by modulating assembly of latent TGF-β binding protein-1 (LTBP1). J. Biol. Chem., 282(36):26418-26430, 2007. Rohe, B., Safford, S., Nemere, I., and Farach-Carson, M.C. Regulation of expression of 1,25D₃-MARRS/ERp57/PDIA3 in rat IEC-6 cells by TGFβ and 1,25(OH)₂D₃. Steroids, 7(2):144-150, 2007. Huang, W.C., Wu, D., Xie, Z., Zhau, H.E., Nomura, T., Zayzafoon, M., Pohl, J., Hsieh, C.L., Weitzmann, M.N., Farach-Carson, M.C., and Chung, L.W. β2-microglobulin is a signaling and growth-promoting factor for human prostate cancer bone metastasis. Cancer Res., 66(18):9108-9116, 2006. Muir, C. , Chung, L.W.K., Carson, D.D., and Farach-Carson, M.C. Hypoxia increases VEGF-A production by prostate cancer and bone marrow stromal cells and initiates paracrine activation of bone marrow endothelial cells. Clin. Exp. Metastasis, 23(1):75-86, 2006. Nemere, I., Wilson, C., Hendricks, D., Jensen,, W., Steinbeck, M., Rohe, B. and Farach-Carson, M.C. Mechanism of 24,25-dihydroxyvitamin D₃-mediated inhibition of rapid, 1,25-dihydroxyvitamin D₃-induced responses: Role of reactive oxygen species. J. Cell Biochem., 99:1572-1581, 2006. Datta, M.W., Hernandez A.M., Schlich M.J., Kahler A.J., Degueme A.M., Dhir R., Shah R.B., Farach-Carson M.C., Barrett A., and Datta, S. Perlecan, a candidate gene for the CABP locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway. Molecular Cancer, 5:9, 2006. Gomes, R.R. Jr., Van Kuppevelt, T.H., Farach-Carson, M.C., and Carson, D.D. Spatiotemporal distribution of heparan sulfate epitopes during murine cartilage growth plate development. Histochem. Cell Biology, 126:713-722, 2006. Bergh, J.J., Shao, Y., Puente, E. Duncan, R.L. and Farach-Carson, M.C. Osteoblast Ca²⁺ Permeability and voltage-sensitive Ca²⁺ calcium channel (VSCC) expression is temporally regulated by 1,25-dihydroxyvitamin D₃. Am. J. Physiol. (Cell Physiol.), 290(3):C822-831, 2006. Gomes, R.R. Jr., Joshi, S.S., Farach-Carson, M.C., and Carson, D.D. Ribozyme-mediated perlecan knockdown impairs chondrogenic differentiation of C3H10T1/2 fibroblasts. Differentiation, 74(1):53-63, 2006. Yang, W.D., Gomes, R.R. Brown, A.J., Burdett, A.R. Alicknavitch, M., Farach-Carson, M.C., and Carson, D.D. Chondrogenic differentiation on perlecan domain I, collagen II, and bone morphogenetic protein 2-based matrices. Tissue Engineering, 12(7):2009-2024, 2006. Savore, C., Liu, Riting, Muir, C., Shu, J., Zhau, H.E., Chung, L.W.K., Carson, D.D., and Farach-Carson, M.C. Perlecan knockdown in prostate cancer cells reduces heparin binding growth factor responses in vitro and tumor growth in vivo. Clin. Exp. Metastasis, 22:377-390, 2005. Yang, W.D., Gomes, R.R., Alicknavitch, M., Farach-Carson, M.C., and Carson, D.D. Perlecan domain I promotes FGF-2 delivery in collagen I fibril scaffolds. Tissue Engineering, 11:76-89, 2005. Al-Shami, R., Sorensen, E.S., Ek-Rylander, B., Andersson, G., Carson, D.D, and Farach-Carson, M.C. Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway. J. Cell Biochem., 94:1218-33, 2005. Shin, H., Temenoff, J.S., Bowden, G.C., Zygourakis, K., Farach-Carson, M.C., Yaszemski, M.J., and Mikos, A.G. Osteogenic differentiation of rat bone marrow stromal cells cultured on Arg-Gly-Asp modified hydrogels without dexamethasone and β-glycerol phosphate. Biomaterials, 17:3645-54, 2005. Hecht, J.T., Hayes, E., Haynes, R., Cole, W.G., Long, R.J., Farach-Carson, M.C., and Carson D.D. Differentiation-induced loss of heparan sulfate in human exostosis derived chondrocytes. Differentiation, 73:212-21, 2005. Rohe, B., Safford, S.E., Nemere, I. and Farach-Carson, M.C. Identification and characterization of 1,25D₃-membrane-associated rapid response, steroid (1,25D₃-MARRS)-binding protein in rat IEC-6 cells. Steroids, 70:458-63, 2005. Go to top of page				People » Faculty Directory » Dr. Mary C. Farach-Carson Shortcuts to: Contact Education Research Interests Current Projects Teaching Research Group Selected Publications E-mail link to this page Printer-friendly format
University of Delaware • Department of Biological Sciences • 118 Wolf Hall • Newark, DE 19716