Genes and Brain: Two Kinds of Physical Constraints

Summary Prepared by John Shackelford, Rishi Khan, and Matthew Huenerfauth

     A complete study of human cognition would involve all three Flanagan/Marr levels; in this segment of the course, we have studied the lowest of these levels: Implementation. More specifically, we have concentrated on genes and the "wetware" of the brain.
What is a Neuron?
     A neuron is fundamental structural unit of the nervous system. There are over one hundred billion of these cells in the human brain - twenty times the current population of the entire world or five-hundred thousand time the number of pixels on a television screen. And they all fit into the space of three pints. There are over one hundred trillion connections between these neurons.
     A neuron can fire up to one thousand times per second. Although this is a thousand times slower than a microchip, the processing capabilities of the human brain still exceed that of any computer - apparently these systems have extremely different modes of operation.
     A neuron is a cell consisting of a nucleus, an axon, and dendrites; the primary function of these cells is to transmit information from one area of the body to another. The largest part of the neuron, the axon, transmits electrical impulses across the cell to dendrites. These regions of the cell receive electrical stimuli and, in response, produce neurotransmitters, chemicals that transfer information between neurons.
Chemical Pathways of the Brain
     Although the brain transmits the majority of the information it processes through electrical intraneural impulses, the chemical transfer of information between neurons is also important. Vacuoles filled with neurotransmitters make their way to the dendritic membrane and are released and travel to other neurons - stimulating the production of an electrical signal. Two examples of neurotransmitters are serotonin and dopamine; they are involved with normal functions of the brain, such as sleep.
The Structure of the Human Brain
     An analysis of the lateral and vertical differentiation of the brain indicates that functional relationships between areas of dedicated processing parallel their spatial orientation. (See the Neuroscience for Kids for a diagram of the structure of the brain.) The presence of all these mediating layers between input and output adds to the complexity and flexibility of the brain.
What is a Gene?
     A gene is the unit of inheritance. It's a piece of the genetic material that determines the inheritance of a particular characteristic, or group of characteristics. Genes are carried by chromosomes in the cell nucleus and are arranged in a line along each chromosome. Genetic material takes the form of deoxyribonucleic acid (DNA), a long ladder-like molecule in the shape of a double helix. The "rungs" of the ladder encode genetic information as a sequence of nucleotides (adenine, guanine, cytosine, and thymine). Cells utilize this genetic information by producing various proteins, the structure of which are stored in the arrangement of nucleotides on the DNA molecule.
How do Genes Influence Behavior?
     Contrary to popular belief, genetic make-up is not the only determinant of brain structure and function; however, it does play a significant role. Genes set the norms of behavior, not its limits. Interactions with the environment are an additional contributor to behavior. The extent of influence each has on the brain is hard to determine.
     In an effort to quantify the influence genes - as opposed to environment - have on behavior, cognitive scientists have conducted various studies of identical twins. The validity of these experiments is extremely difficult to ensure because, even when the twins are raised apart, their genetic similarities lead them to encounter similar environments.
     There is also significant research aimed at tracing the link from behavior back to its genetic roots. Comparing William's Syndrome, Turner's Syndrome, and Simultagnosia, we see that the same behavior at the ecological level can be attributed to different bases at the implementation level. This analysis also indicated that it is not always possible to trace an ecological disorder down through every other Flanagan/Marr level.
Evolutionary Theory
     Our brain is the result of millions of years of evolution. The earliest named hominoid species lived between three and four million years ago, and evidence suggests that meat eating began two to three million years ago. One million years later, man began to develop stone tools and harness fire. Thirty-two thousand years ago Neanderthal man became extinct, and Cro-Magnon man, our earliest ancestor with a brain nearly identical to ours, lived fifty to seventy-five thousand years ago.