William B. Farquhar
Associate Professor

Research Interests

• Cardiovascular Physiology
• Exercise Physiology

Email: wbf@udel.edu
Phone: 302-831-6178
FAX: 302-831-3693

541 South College Avenue
Fred Rust Arena, HPL #143
University of Delaware, Newark, DE 19716

Education

Positions and Employment

1991-1992	Exercise Physiologist, Department of Cardiology, Easton Hospital, Easton, PA
1992-1994	Exercise Physiologist, Cardiac Rehabilitation Department, Lehigh Valley Hospital, Allentown, PA
1994-1998	Graduate Assistant, Department of Kinesiology, Penn State University, University Park, PA
1998-2001	Research Fellow, Department of Neurology, BIDMC, Harvard Medical School, Boston, MA
2001-2002	Instructor in Medicine, Harvard Medical School Division on Aging, Boston, MA and Research Assistant Scientist, HRCA Research and Training Institute, Boston, MA
2002	Assistant Professor, University of Delaware, Department of Health, Nutrition, and Exercise Sciences, Newark, DE
2002	Faculty, Biomechanics and Movement Science Interdisciplinary Master’s and PhD Program, University of Delaware, Newark, DE
2004	Specified Health Professional (Research Privileges), Department of Medicine, Section of Cardiology, Christiana Care Health Services, Newark, DE
2007	DBI Affiliated Faculty, Delaware Biotechnology Institute, Newark, DE

Courses

• HESC 802, Human Cardiovascular Control
• HESC 800, Advanced Exercise Physiology
• HESC 675, Cardiovascular Assessment II
• HESC 603, Graduate Seminar in Exercise Science
• HESC 353, Undergraduate Seminar in Exercise Science

Professional Memberships

1995 American Physiological Society
1991 American College of Sports Medicine (Fellow 2004- )
2006 American Heart Association

Professional Committee Assignments

Certifications

Editorial Contributions

Peer Reviewed Publications

1. Kenney WL, Morgan AL, Farquhar WB, Brooks EM, Pierzga JM, and Derr JA. Decreased active vasodilator sensitivity in aged skin. Am J Physiol 272: H1609-1614, 1997.

2. Farquhar WB and Kenney WL. Age and renal prostaglandin inhibition during exercise and heat stress. J Appl Physiol 86: 1936-1943, 1999.

3. Farquhar WB, Morgan AL, Zambraski EJ, and Kenney WL. Effects of acetaminophen and ibuprofen on renal function in the stressed kidney. J Appl Physiol 86: 598-604, 1999.

4. Farquhar WB and Kenney L. Renal effects of ibuprofen during sodium restriction in the aged. J Am Geriatr Soc 48: 106-108, 2000.

5. Farquhar WB, Taylor JA, Darling SE, Chase KP, and Freeman R. Abnormal Baroreflex Responses in Patients With Idiopathic Orthostatic Intolerance. Circulation 102: 3086-3091, 2000.

6. Hunt BE, Fahy L, Farquhar WB, and Taylor JA. Quantification of mechanical and neural components of vagal baroreflex in humans. Hypertension 37: 1362-1368, 2001.

7. Hunt BE, Farquhar WB, and Taylor JA. Does reduced vascular stiffening fully explain preserved cardiovagal baroreflex function in older, physically active men? Circulation 103: 2424-2427, 2001.

8. Volek JS, Mazzetti SA, Farquhar WB, Barnes BR, Gomez A, and Kraemer WJ. Physiological responses to short-term exercise in the heat after creatine loading. Med Sci Sports Exerc 33: 1101-1108, 2001.

9. Farquhar WB, Hunt BE, Taylor JA, Darling SE, and Freeman R. Blood volume and its relation to peak O(2) consumption and physical activity in patients with chronic fatigue. Am J Physiol Heart Circ Physiol 282: H66-H71, 2002.

10. Freeman R, Lirofonis V, Farquhar WB, and Risk M. Limb venous compliance in patients with idiopathic orthostatic intolerance and postural tachycardia. J Appl Physiol 93: 636-644, 2002.

11. Myers CW, Farquhar WB, Forman DE, Williams TD, Dierks DL, and Taylor JA. Carotid Distensibility Characterized via the Isometric Exercise Pressor Response. Am J Physiol Heart Circ Physiol, 283 (6): H2592-8, 2002.

12. Pescatello LS, Franklin BA, Faggard R, Farquhar WB, Kelley GA, Ray CA. Exercise and Hypertension: American College of Sports Medicine Position Stand. Med. Sci. Sports Exerc. 36: 533-553; 2004.

13. Hunt BE and Farquhar WB. Nonlinearities and asymmetries of the human cardiovagal baroreflex. Am J Physiol Regul Integr Comp Physiol 288: R1339-1346, 2005.

14. Farquhar WB , Paul EE, Prettyman AV, and Stillabower ME. Blood Pressure and Hemodynamic Responses to an Acute Sodium Load in Humans. J Appl Physiol, 99: 1545-1551, 2005.

15. Wenner MM, Prettyman AV, Maser RE, Farquhar WB. Preserved Autonomic Function in Amenorrheic Athletes. J Appl Physiol Epub ahead of print May 18 th,2006.

16. Farquhar WB, Wenner MM, Delaney EP, Prettyman AV, Stillabower ME. Sympathetic Neural Responses to Increased Osmolality in Humans. Am J Physiol Heart Circ PhysiolEpub ahead of print June 9 th 2006.

17. Young CN, Stillabower ME, DeSabatino A, Farquhar WB. Venous Smooth Muscle Tone and Responsiveness in Older Adults. J Appl Physiol accepted for publication 2006.

18. Schell K, Richards JG and Farquhar WB. The Effects of Anatomical Structures on Adult Forearm and Upper Arm Non-invasive Blood Pressures. Blood Pressure Monitoring, Feb;12(1):17-22, 2007.

19. Wenner MM, Delaney EP, Rose WC, Stillabower ME, Farquhar WB. The Influence of Plasma Osmolality on Baroreflex Control of Sympathetic Activity. Am J Physiol Heart Circ Physiol, Oct; 293(4): H2319-9, 2007.

20. Young CN, Prasad RY, Fullenkamp AM, Stillabower ME, Farquhar WB, and Edwards DG. Ultrasound Assessment of popliteal vein compliance during a short deflation protocol. J Appl Physiol, May; 104(5): 1374-80, 2008.

21. Delaney EP, Young CN, DiSabatino A, Stillabower ME, Farquhar WB. Limb venous tone and responsiveness in hypertensive humans. J Appl Physiol, Sep; 105(3): 894-901, 2008.

22. Maser RE, Stabley JN, Lenhard MJ, Owusu-Griffin P, Provost-Craig MA, Farquhar WB. Zinc intake and biochemical markers of bone turnover in type 1 diabetes. Diabetes Care, Dec; 31(12): 2279-80.

23. Sausen MT, Delaney EP, Stillabower ME, Farquhar WB. Enhanced metaboreflex sensitivity in hypertensive humans. Eur J Appl Physiol, Feb;105(3):351-6.

24. Reisman DS, Rudolph KS, Farquhar WB. Influence of speed on walking economy poststroke. Neurorehabil Neural Repair, epub ahead of print Jan 6, 2009.

Misc. Publications (editorials, book chapters, technical reports, etc.)

1. Farquhar WB, Kenney, WL. Anti-inflammatory drugs, kidney function, and exercise [review]. GSSE 11; 1997 .

2. Farquhar WB and Kenney WL. Temperatures in protective head gear padding during simulated

ice hockey [technical report]. Report to: HECC, 1998.

3. Buskirk ER, Farquhar WB. Sodium in exercise and sport [chapter]. In: Macronutrients, electrolytes and macroelements in sports nutrition: CRC Press; 1999.

4. Forman DE, Farquhar W. Cardiac Rehabilitation and Secondary Prevention Programs for Elderly Cardiac Patients [chapter]. Clin Geriatr Med. 16:619-630; 2000.

5. Farquhar WB, Zambraski EJ. ACSM Abstracts: A need for more data [commentary]. Med. Sci. Sports Exerc. 32:2146-2147; 2000.

6. Frey IC, Farquhar WB. Summer Exercise Tips For Older Adults [for the lay public]. ACSM Fit Society Page. 2001.

7. Farquhar WB, Zambraski EJ. The effects of creatine use on the athlete’s kidney [review]. Current Sports Medicine Reports. 1:103-106; 2002.

8.Wenner MM, Irwin S, and Farquhar WB. Exercise Treatment of the Rehabilitated Patient: Cardiopulmonary and Peripheral Responses [book chapter]. Will be published in: Orthopaedic Physical Therapy, 2009.

Research Abstracts 2000-(presented at National Meetings)

1. Farquhar WB, Ferrucci MM, Hunt BE, Melville SK, Taylor JA. Baroreflex hysteresis in humans: evidence for neural mechanisms (abstract). The FASEB Journal. 2000;14:A385.

2. Farquhar WB, Hunt BE, Taylor JA, Freeman R. The use of NO vs. non-NO donors to assess baroreflex function in humans (abstract). Clinical Autonomic Research. 2000;10:233.

3. Farquhar WB, Freeman R, Hunt BE, Darling SE, Taylor JA. The human arterial baroreflex: can a simple line adequately model a sigmoid relation? (abstract). The Physiologist. 2000;43:281.

4. Taylor JA, Farquhar WB, Hunt BE. The human arterial baroreflex : isn't it hysteretical? (abstract). The Physiologist. 2000;43:282.

5. Hunt BE, Farquhar WB, Taylor JA. The use of nitrovasodilators is appropriate for baroreflex testing (abstract). Clinical Autonomic Research. 2000;10:233.

6. Risk MR, Lirofonis VA, Farquhar WB, Freeman R. Biphasic assessment of venous compliance before and after sympathetic stress (abstract). Clinical Autonomic Research. 2001.

7. Farquhar WB, Lipman RD, Bonyhay I, Kannam J, Taylor JA. Sympathetic neural outflow in patients with coronary artery disease (abstract). Med. Sci. Sports Exerc. 2002.

8. Young CN, Stillabower ME, Farquhar WB. Effects of sublingual nitroglycerin on venous hemodynamic function in young adults (abstract). The FASEB Journal. 2005.

9. Paul EE, Prettyman AV, Stillabower ME, Farquhar WB. Central hemodynamic responses to an acute sodium load (abstract). The FASEB Journal. 2005.

10. Wenner MM, Prettyman AV, Farquhar WB. Autonomic function in amenorrheic athletes (abstract). Med. Sci. Sports Exerc. 2005.

11. Young CN, Stillabower ME, and Farquhar WB. Effects of smooth muscle tone on venous hemodynamic function in young and older adults (abstract). The FASEB Journal 2006.

12. Delaney EP, Wenner MM, Prettyman AV, Stillabower ME and Farquhar WB. Central hemodynamic responses to an acute sodium load in black and white adults (abstract). The FASEB Journal 2006.

13. Wenner MM, Delaney EP, Prettyman AV, Stillabower ME and Farquhar WB. Muscle sympathetic nerve activity during a sodium and volume load (abstract). The FASEB Journal 2006.

14. Kuczmarski JM, Wenner MM, Delaney EP, Prettyman AV, Stillabower ME and Farquhar WB. Lack of association between body mass index and acute hypertonic saline induced increases in blood pressure (abstract). The FASEB Journal 2006.

Certifications

1991-2005	Advanced Cardiac Life Support, American Heart Association
1991	Advanced Cardiac Life Support & CPR, American Heart Association
1991	ACSM Exercise Specialist ® American College of Sports Medicine

Editorial Contributions

1998-2003 Ad hoc reviewer, Journal of Applied Physiology

1998 Ad hoc reviewer, Medicine & Science in Sports and Exercise

1998 Ad hoc reviewer, American Journal of Physiology

1998 Ad hoc reviewer, Clinical Autonomic Research (currently named Autonomic Neuroscience)

2003 Member, Editorial board, Journal of Applied Physiology

2005 Ad hoc reviewer, Autonomic Neuroscience: Basic and Clinical

2006 Ad hoc reviewer, American Journal of Physiology - Heart & Circulatory Physiology

2006 Ad hoc reviewer, America Journal of Cardiology

2006 Ad hoc reviewer, Journal of Physiology London

University Teaching

1996 Clinical Electrocardiography – 2 credit class Penn State University

1997 Exercise Prescription – 3 credit class Penn State University

1995-98 Exercise Specialist Workshop – 1 week, annual East Stroudsburg University

1997-98 Health and Fitness Workshop – 1 week, annual Indiana University of Penn

1994-97 Case Studies in Exercise Science – 1 credit class Penn State University

1996 Fitness Appraisal – 1 credit laboratory class Penn State University

2002 Advanced Physiology of Exercise – 3 credit grad. class University of Delaware

2003 Human Cardiovascular Control – 3 credit grad. class University of Delaware

2003 Cardiovascular Assessment II - 3 credit grad. class University of Delaware

2003 Seminar in Exercise Phys. – 1 credit undergrad. class University of Delaware

2004-05 Human Cardiovascular Control – 3 credit grad. class University of Delaware

2005 Seminar in Exercise Physiology – 1 credit grad. class University of Delaware

2005 Physiology of Activity – 3 credit class (team-taught) University of Delaware

2005 Advanced Physiology of Exercise – 3 credit grad. class University of Delaware

2006 Physiology of Activity – 3 credit undergraduate class University of Delaware

University Service (Departmental )

2005- Safety Committee
2004- Graduate Studies Committee

Invited Presentations

2000 Department of Kinesiology, University of Massachusetts --Seminar
2001 John B. Pierce Laboratory, Yale University School of Medicine --Seminar
2001 New England Regional Chapter of ACSM --Symposium
2002 U.S. Army Research Institute of Environmental --Medicine Seminar
2005 Noll Physiological Research Seminar Series at Penn --State Seminar
2006 John B. Pierce Laboratory, Yale University School of Medicine --Seminar
2006 Department of Exercise Science, University of Massachusetts --Seminar
2006 Vascular Biology Workshop, University of Florida --Workshop

Students Supervised by PI (within the last 3 years)

Undergraduate Students
Kathleen M. DiBiase (Nursing student, worked 30 hours per week in the lab during the 2005 summer)
James M. Kuczmarski (participated in the summer scholars program plus an independent study in 2006)
Ryan Allen (participated in the summer scholars program plus an independent study in 2004)
Lauren Tavani (3-credit independent study during the Spring ’05 semester)
Chris Raisan (3-credit independent study during the Spring ’05 semester)
Christopher–Michael Gale (participated in the summer scholars program during the 2003 summer)
Erin Kardine (summer scholars program during the 2004 summer)
Jennifer Wajnold (3-credit independent study during the Spring ’05 semester)

Graduate Students
Megan M. Wenner (current PhD student in my lab)
Erin P. Delaney (current PhD student in my lab)
Colin N. Young (graduated with M.S. degree in 2005; accepted in the Univ. of Missouri PhD program in Pharmacology and Physiology)

Research Support: Ongoing

2 R15 HL074851-02 Farquhar (PI) 5/3/07 – 4/30/09
NIH-NHLBI
Project Title: Sympathetic – Osmotic Interactions in Humans
Role: PI
The purpose of this project is to investigate the osmotic regulation of sympathetic nervous system activity in humans that are classified as salt sensitive and compare to humans that are classified as salt resistant.

AHA Proposal Reisman (PI) 7/1/07 – 6/30/09
Project title: Relationship between speed and walking function following stroke
Role: Co-I
The goal of this project is to examine metabolic cost and overall economy of walking in patients that have suffered a stroke.

5 R01 NR010786 Binder-Macleod (PI) 9/12/07 – 5/31/12
NIH-NINR
Project Title: Fast Treadmill Training/Functional Electrical Stimulation to Improve Walking Post Stroke
Role: Co-I
The overall goal of this project is to develop a physiologically based intervention to improve functional ambulation in individuals who have sustained a stroke.

5 R01 HL071159-05 Stachenfeld (PI) 5/1/08 – 4/30/09
NIH-NHLBI
Project Title: Estrogen and Progesterone Effects on Orthostatic Tolerance
Role: Co-I, oversee subcontract
The purpose of this project is to determine the effects of estradiol and progesterone on sympathetic outflow and cardiovagal baroreflex function and to determine the effects of these hormones on peripheral blood flow in women with high and low orthostatic tolerance.

Research Support: Pending

2 P20 RR016472-08 Weir (PI) 5/1/09 – 4/30/12
NIH-NCRR
Overall Project Title: Delaware INBRE IDeA Network of Biomedical Research Excellence
Role: Co-I (oversee subproject titled: Physiological Effects of Dietary Sodium in Salt Resistant Humans)
The purpose of this subproject is to examine the effects of dietary salt on circadian blood pressure rhythm, arterial vascular function, and venous vascular function in a group of salt resistant humans.

Research Support: Completed (during the last 3 years)

1 R03 AG023836-01A1 Farquhar (PI) 1/01/05 – 12/31/06
National Institute on Aging
Project Title: Venous Hemodynamic Function in Older Hypertensive Adults
Role: PI
The purpose of this project was to investigate age- and disease-related differences in limb venous compliance and smooth muscle tone.

R15 HL074851-01 Farquhar (PI) 2/23/04 – 1/31/07
National Heart, Lung, and Blood Institute
Project Title: Sympathetic – Osmotic Interactions in Humans
Role: PI
The purpose of this project was to investigate the osmotic regulation of sympathetic nervous system activity in humans.

5 R43 HL077016-02 Hyde (PI) 4/1/06 – 3/31/08
NHLBI
Project Title: Real-Time Angiotensin Monitor for Salt Sensitivity
Role: consultant, oversee subcontract
The purpose of this project was to assess physiological responses to an acute, oral salt load, including blood pressure and heart rate variability.

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